Effects of a New Hypoglycemic Chinese Herbal Prescription on STZ Induced Diabetes Mellitus in Mice

DANG Jingjing;WANG Wei;SONG Xiaobao;LIU Gaoran;SHAO Baojian;WU Guojiang;College of Life Science,Hebei Agricultural University;

STZ induction;;diabetes mellitus;;Radix Puerariae;;Salvia miltiorrhiza;;semen hoveniae

To obtain Chinese herbal prescription for curing diabetes mellitus,the authors explored the efforts and potential mechanism of a Chinese herbal prescription,which was composed of root of kudzu vine,root of red-rooted salvia and semen hoveniae,on diabetes mellitus.Streptozotocin(STZ)was used to establish the model of diabetes mellitus,and the model was established with fasting blood glucose of 11mmol/L.30 mice were randomly divided into blank control group,experimental group and negative control group,10 mice in each group.The experimental group was given the decoction every day,the blank group and the negative control group were given the same dose distilled water every day.The mice's liver and kidney physiological index changes were detected as well.Results:fasting glucose levels in diabetic mice induced by STZ was reduced after seven days,the test group compared with the negative control group decreased the fasting blood glucose,weight recovery,liver index(ALB)reduced by 31.58%,alkaline phosphatase(ALP)decreased by 57.43%,alanine aminotransferase(ALT)increased by 87.80%,aspartate aminotransferase(AST)decreased by 51.72%,total protein(TP)decreased by 31.94%.Traditional Chinese medicine prescription has a significant effect on the treatment of diabetes mellitus with a concentration of 1g/L.