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当前位置: 首页 > 文章 > 染料木素锌、铜金属配合物的制备及抗癌活性研究 大豆科学 2022 (1) 91-98
Position: Home > Articles > Studies on the Preparation and Anticancer Activity of Genistein Zinc and Genistein Copper Complexes Soybean Science 2022 (1) 91-98

染料木素锌、铜金属配合物的制备及抗癌活性研究

作  者：
王有娣;彭俊梅;刘铭美;徐娟娟
单  位：
广州新华学院药学院;南华大学药学院
关键词：
大豆;染料木素;锌配合物;铜配合物;合成;抗癌活性
摘  要：
为研究大豆中异黄酮类成分染料木素锌、铜金属配合物的制备方法及其抗癌活性,以染料木素为配体,设计并合成染料木素-锌、染料木素-铜配合物,利用红外光谱、紫外光谱、热重分析等方法对配合物进行表征,并通过MTT法考察染料木素及其锌、铜金属配合物对人非小细胞肺癌细胞A549、人乳腺癌细胞MCF-7及人脐静脉内皮细胞HUVEC的增殖抑制作用。表征结果表明:试验成功制备得到染料木素-锌、染料木素-铜配合物。MTT试验结果表明:染料木素-锌、染料木素-铜配合物均对MCF-7和A549细胞增殖有抑制效果,且抑制作用高于其配体染料木素,而对于正常细胞人脐静脉内皮细胞HUVEC的增殖无明显抑制活性。
译  名：
Studies on the Preparation and Anticancer Activity of Genistein Zinc and Genistein Copper Complexes
作  者：
WANG You-di;PENG Jun-mei;LIU Ming-mei;XU Juan-juan;School of Pharmacy, Guangzhou Xinhua University;College of Pharmacy, University of South China;
关键词：
soybean;;genistein;;zinc complexe;;copper complexe;;synthesis;;anticancer activity
摘  要：
In order to study the preparation method and anticancer activity of genistein-zinc and genistein-copper metal complexes, genistein was used as a ligand, and then it was combined with zinc and copper to synthesize genistein-zinc and genistein-copper metal complexes. Metal complexes were characterized by IR, UV and thermogravimetric analysis. The inhibitory effects of genistein and its zinc and copper complexes on the proliferation of human non-small cell lung cancer cell line A549, human breast cancer cell MCF-7 and human umbilical vein endothelial cell HUVEC were investigated by MTT method. The results showed that genistein-zinc and genistein-copper complexes were successfully prepared, and the MTT assay results showed that genistein-zinc and genistein-copper complexes had inhibitory effects on the proliferation of MCF-7 and A549 cells, and the inhibitory effects were higher than genistein, however, genistein-zinc and genistein-copper complexes had no obvious inhibitory effects on the proliferation of HUVEC cells.

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