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Position: Home > Articles > Effect of Qiangtongning on Na~+-K~+-ATPase activity in central brain regions of rats Heilongjiang Animal Science and Veterinary Medicine 2016 (13) 194-196+200

强痛宁对大鼠中枢脑区Na~+-K~+-ATP酶活性的影响

作者：

尹柏双;沙万里;李宇航;呼显生;付连军

单位：

预防兽医学吉林省重点实验室;吉林农业大学动物科技学院;吉林农业科技学院动物医学学院

关键词：

强痛宁;麻醉;大鼠;中枢系统;脑区;Na+-K+-ATP酶

摘要：

为了探讨强痛宁麻醉镇痛作用与中枢脑区Na~+-K~+-ATP酶的相关性,试验选取24只纯种SD大鼠随机分成对照组、诱导组、麻醉组和催醒组,于各时间点冰上采集大鼠各脑区,采用比色法测定Na~+-K~+-ATP酶活性。结果表明:药物作用后诱导期及麻醉期大鼠大脑皮质、小脑内Na~+-K~+-ATP酶活性显著低于对照组(P<0.01),海马、丘脑及脑干区Na~+-K~+-ATP酶活性与对照组比较极显著降低(P<0.01),催醒期各脑区Na~+-K~+-ATP酶活性恢复到麻醉前水平。说明强痛宁可引起大鼠各脑区Na~+-K~+-ATP酶活性降低,阻碍神经细胞对痛觉刺激信息的传导,产生了麻醉镇痛作用。

译名：

Effect of Qiangtongning on Na~+-K~+-ATPase activity in central brain regions of rats

作者：

YIN Baishuang;SHA Wanli;LI Yuhang;HU Xiansheng;FU Lianjun;College of Veterinary Medicine,Jilin Agricultural Science and technology;Key Laboratory of Preventive Veterinary Medicine in Jilin Province;College of Animal Science and Technology,Jilin Agricultural University;

关键词：

Qiangtongning;;anesthesia;;rat;;central nervous system;;brain region;;Na~+-K~+-ATPase

摘要：

To explore the correlation between the narcotic analgesic effects of Qiangtongning and Na~+-K~+-ATPase in central brain regions,24 pure-bred SD rats were randomly divided into a control group,an induction group,an anesthesia group and a wake group.Brain samples were collected from the rats on the ice at different time points.The activity of Na~+-K~+-ATPase in the samples was determined by using colorimetric assay.The results showed that the activity of Na~+-K~+-ATPase in cerebral cortex and cerebellum was extremely significantly lower(P < 0.01) than that of the control group during the induction and anesthesia after administration; the activity of Na~+-K~+-ATPase in hippocampus,thalamus and brain stem was extremely significantly decreased(P < 0.01) compared with that of the control group; the activity of Na~+-K~+-ATPase in different brain regions were recovered to the level before anesthesia in the waking period.The results indicate that Qiangtongning can cause the activity of Na~+-K~+-ATPase in different brain regions to reduce in rats and hinders the nerve cells to transmit pain stimulus information,resulting in a narcotic analgesic effect.

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强痛宁对大鼠中枢脑区Na~+-K~+-ATP酶活性的影响

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