Position: Home > Articles > Recent Advances in Plant-derived Recombinant Pharmaceutical Proteins Produced in Plant Seeds
Journal of Nuclear Agricultural Sciences
2014,28
(9)
1597-1605
基于种子生产植物源重组药物蛋白研究进展
作 者：
蒋滢;杨静;齐广勋;邢国杰;马莲菊;杨向东
单 位：
吉林省农业科学院农业生物技术研究所;沈阳师范大学化学与生命科学学院
关键词：
植物源重组药物蛋白;种子;植物反应器;研究进展
摘 要：
种子作为植物重要储藏器官之一,为高效表达外源重组药物蛋白提供了理想的载体。与其他植物生产系统相比,植物种子反应器具有多方面的优势,如表达水平较高,重组蛋白活性稳定,易于储藏和运输以及便于加工、分离和纯化等。在过去的20年中,利用植物种子作为反应器表达了一系列重组药物蛋白,部分药物蛋白已进入商业化生产阶段。本文对种子生物反应器的特点及利用,就近年来基于种子生产植物源重组药物蛋白的研究进展进行了综述,并对植物种子生物反应器研究中的几个问题及未来的发展方向进行了探讨。
译 名：
Recent Advances in Plant-derived Recombinant Pharmaceutical Proteins Produced in Plant Seeds
作 者：
JIANG Ying;YANG Jing;QI Guang-xun;XING Guo-jie;MA Lian-ju;YANG Xiang-dong;College of Chemistry and Life Science,Shenyang Normal university;Agricultural Biotechnology Research Institute,Jilin Academy of Agriculture Science;
关键词：
Plant-derived recombinant pharmaceutical proteins;;Seeds;;Plant bioreactors;;Research progress
摘 要：
As an important storage compartment of plants,seeds are promising a desirable platform for production of large quantity of recombinant pharmaceutical proteins. Among different plant-based system, plant seeds hold several advantages such as high protein yields,long-term stability of target proteins,easiness of storage and transplantation,suitability of later extraction and recovery. In the past two decades,significant advances in using seeds as bioreactors have occurred for production of many recombinant proteins with some of them moving down the commercialization pipeline. Here we give some brief introductions of characteristics of seed bioreactor and review the current progress on plant-derived recombinant pharmaceutical proteins produced in plant seeds, and some considerations and future development for plant seed-derived pharmaceuticals production are also discussed in this paper.
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