Position: Home > Articles > Advance on 3β-Hydroxysteroid Dehydrogenase and 7β-Hydroxysteroid Dehydrogenase
China Animal Husbandry & Veterinary Medicine
2011,38
(8)
68-72
3β和17β羟基类固醇脱氢酶的研究进展
作 者：
董新星;方美英;陈刚
单 位：
中国农业科学院农业质量标准与检测技术研究所;中国农业大学动物科技学院
关键词：
3β羟基类固醇脱氢酶;17β羟基类固醇脱氢酶;基因结构;转录调控
摘 要：
3β羟基类固醇脱氢酶(3β-hydroxysteroid dehydrogenase,3βHSDs)和17β羟基类固醇脱氢酶(17β-hydroxysteroid dehydrogenase,17βHSDs)是所有固醇类激素生成及激素活性和非活性之间互相转化的关键酶,对于维持哺乳动物体内激素之间的平衡、调节激素生成和代谢发挥着重要的作用。作者综述了3βHSDs和17βHSDs基因的结构及功能、表达及组织分布、基因的转录调控,以及两种酶与养猪生产间的关系。
译 名：
Advance on 3β-Hydroxysteroid Dehydrogenase and 7β-Hydroxysteroid Dehydrogenase
作 者：
DONG Xin-xing1,FANG Mei-ying1,CHEN Gang2(1.College of Animal Science and Technology,China Agricultural University,Beijing 100193,China; 2.Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences,Beijing 100081,China)
关键词：
3β-hydroxysteroid dehydrogenase;17β-hydroxysteroid dehydrogenase;gene structure;transcription regulation
摘 要：
The two enzymes 3β-hydroxysteroid dehydrogenase(3βHSDs) and 17β-hydroxysteroid dehydrogenase(17βHSDs) are essential for the conversion of all steroid hormones from non-active to their active forms,which play an important role in regulating the balance between hormones and maintaining the normal physiological functions in mammals.Here we presented 3βHSDs and 17βHSDs gene molecular structure and function,tissu-specific expression,as well as regulation of transcription.Moreover,the relation of these two enzymes in pig production was also reviewed.
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