Position: Home > Articles > Persisters and their effects on microbial biofilm tolerance: A review
Chinese Journal of Applied Ecology
2010,21
(10)
2707-2714
持留菌及其对微生物膜的耐受性影响研究进展
作 者：
龙冬艳;胡少平;陈新才;刘磊;陈英旭
单 位：
浙江大学水环境研究院
关键词：
持留菌;微生物膜;毒素-抗毒素分子;多药耐性;金属耐性
摘 要：
持留菌(persisters)是细菌种群中所占比例不到0.1%的一类特殊亚群,具有与种群内普通菌、抗性突变菌所不同的特征,其形成机制复杂,不易分离培养.持留菌可通过"休眠-生长-增殖"应对逆境的胁迫,维持自身生存和菌体结构稳定,在生物膜的多药耐受性与多金属耐性中发挥着重要作用,对于维持微生物群落结构稳定具有重要意义.本文从持留菌的研究历程、特点、基因调控机制及其对微生物膜的耐药性与多金属耐性的影响等方面进行了综述,并对今后的研究方向进行了展望.
译 名：
Persisters and their effects on microbial biofilm tolerance: A review
作 者：
LONG Dong-yan,HU Shao-ping,CHEN Xin-cai,LIU Lei,CHEN Ying-xu(Academy of Water Science & Environmental Engineering,Zhejiang University,Hangzhou 310029,China)
关键词：
persisters;microbial biofilm;toxin-antitoxin(TA) modules;multi-drug tolerance(MMD);multi-metal tolerance(MMT)
摘 要：
Persisters are a group of special subpopulation of bacteria,only occupying < 0.1% of the whole population but having the characteristics different from the ordinary bacteria and resistant mutants.They have complex formation mechanism,and are difficult to isolate and culture.The persisters can adapt to the adverse environment via "dormancy-growth-proliferation"to maintain their survival and cell structure stability,and play a vital role in the multi-drug and multi-metal tolerance of microbial biofilm,being of great significance in maintaining the stability of microbial community structure.This paper reviewed the research progress on the characteristics of persisters,their gene regulation mechanisms,and their effects on the multi-drug and multimetal tolerance of microbial biofilm.The related research directions in the future were also prospected.
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