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TGF-β家族成员调控家禽卵泡发育的研究进展及展望

作  者:
李琴;王启贵
单  位:
重庆市畜牧科学院
关键词:
家禽;FSH;TGF-β;AMH;卵泡发育
摘  要:
与哺乳动物不同,家禽的卵泡发育无明显发情周期,其卵泡发育遵循严格的等级发育体系.禽类卵泡的等级发育是一个复杂的调节过程,受卵泡细胞内外的内分泌激素、自分泌/旁分泌因子的共同调节.促卵泡刺激素(Follicle stimulating hormone,FSH)和促黄体激素(Luteinizing hormone,LH)在调控卵泡发育、卵母细胞成熟和排卵中起着重要的作用.此外,局部产生的生长因子如转化生长因子β超家族(Transforming growth factor superfamily,TGF-β)成员,包括抗缪勒氏激素(Anti-Müllerian hormone,AMH)、骨形态蛋白家族(Bone morphogenetic proteins,BMPs)、抑制素(Inhibin)和激活素(Activin)等,与促性腺激素一起协同调控卵泡的生长发育、卵母细胞的成熟等过程.文章综述了TGF-β家族成员,包括AMH、BMPs、抑制素、激活素在家禽卵泡发育中的作用及其未来的研究方向.
作  者:
LI Qin;WANG Qigui;Chongqing Academy of Animal Sciences;Chongqing Engineering Research Center of Goose Genetic Improvement;
关键词:
poultry;;FSH;;TGF-β;;AMH;;follicle development
摘  要:
Unlike mammals, follicle development in poultry has no apparent estrous cycle. In birds, follicular development follows a strict hierarchical development system. The follicle development is co-regulated by endocrine hormones, autocrine and paracrine factors secreted by intrafollicular and extrafollicular tissue or cells. Follicle-stimulating hormone(FSH) and luteinizing hormone(LH) play an important role in follicle development, oocyte maturation and ovulation. Furthermore, growth factors locally produces such as transforming growth factor superfamily-β(TGF-β)members, including anti-Müllerian hormone(AMH), bone morphogenetic proteins(BMPs), inhibin, and activin, have been found to have a substantial synergistic effect with gonadotrophins on avian follicle development, oocyte maturation and ovulation. This review summarized the role of TGF-β family members including AMH, BMPs, inhibin, and activin during follicle development and future research directions in poultry.

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