当前位置: 首页 > 文章 > 鱼类干扰素调节因子IRF4亚家族进化及分化分析 扬州大学学报(农业与生命科学版) 2014,35 (2) 15-20
Position: Home > Articles > Gene evolution and divergence of interferon regulatory factors IRF4 subfamily in teleost fish Journal of Yangzhou University(Agricultural and Life Science Edition) 2014,35 (2) 15-20

鱼类干扰素调节因子IRF4亚家族进化及分化分析

作  者:
庹锐;万晶;杨代勤;许巧情
单  位:
长江大学湿地生态与农业利用教育部工程研究中心
关键词:
硬骨鱼类;干扰素调节因子;进化
摘  要:
为比较干扰素调节因子(IRF)4、IRF8、IRF9和IRF10在硬骨鱼类中的进化和分化情况,构建系统进化树,并采用非同义替代(Ka)与同义替代(Ks)的比值计算这几种基因在硬骨鱼类中进化率。结果表明:IRF4、IRF8、IRF9和IRF10在进化树上各成一支,硬骨鱼类IRF4进一步分化为IRF4a和IRF4b。4个基因的Ka/Ks值均小于1,说明这些基因在硬骨鱼类进化过程中是负选择,提示在不同物种中这些基因保持原有的功能并趋于稳定。尽管如此,不同基因进化速率存在明显差异。IRF9、IRF10、IRF4a、IRF4b和IRF8进化率分别为0.50、0.30、0.20、0.25和0.15。充分表明在硬骨鱼类进化过程中IRF8、IRF4a和IRF10分化程度低,而IRF4b和IRF9分化程度高。
译  名:
Gene evolution and divergence of interferon regulatory factors IRF4 subfamily in teleost fish
作  者:
TUO Rui;WAN Jing;YANG Daiqin;XU Qiaoqing;Engin Res Cen of Eco and Agric Use of Wetland,MOE,Yangtze Univ;
关键词:
teleost fish;;interferon regulatory factors;;evolution
摘  要:
IRF4,IRF8,IRF9and IRF10belong to IRF4subfamily in interferon regulatory factor family.The phylogenetic tree and evolutionary rate of IRF4,IRF8,IRF9and IRF10were compared in the study,which would elucidate the conservation and diversification in evolution about the four genes in bony fishes.Evolutionary rate was calculated with the ratio of nonsynonymous to synonymous substitution rates(Ka/Ks).The results showed that IRF4,IRF8,IRF9and IRF10clustered to a group respectively and IRF4genes were consisted of IRF4aand IRF4b.The average Ka/Ksratios of four genes in IRF4subfamily among different bony fishes were all less than 1,indicating they were under purifying selection.However,evolutionary rate between them was different.The Ka/Ksratio was about 0.50,0.30,0.20,0.25and 0.15for IRF9,IRF10,IRF4a,IRF4band IRF8,respectively.All these data proved that IRF8,IRF4aand IRF10showed higher conservation while IRF4b and IRF9presented higher diversification in bony fish.

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