Position: Home > Articles > Study on Preparation and Characteristics of Microcapsule of Ivermectin
Chinese Journal of Veterinary Drug
2011,45
(12)
35-38
伊维菌素微胶囊的制备及其性质研究
作 者：
卢景秀;谭伟;赵肃清;郑广浩;姚敏杰;丁倩
单 位：
广东工业大学轻工化工学院
关键词：
伊维菌素微胶囊;辛烯基琥珀酸酯化淀粉;高效液相色谱法
摘 要：
对伊维菌素微胶囊进行制备、表征及其性质研究。以辛烯基琥珀酸酯化淀粉为壁材,伊维菌素为芯材,按照一定比例混合后,进行超声乳化,冷冻干燥14 h得到微胶囊。红外光谱法对微胶囊产品进行表征,高效液相色谱法对伊维菌素含量进行测定,同时研究了光照和温度对其稳定性的影响。结果表明:用冷冻干燥法制备的微胶囊的包封率可达到92.27%;连续光照5 h和在30～60℃下保存24 h,微胶囊性质稳定;红外图谱显示微胶囊制备成功。冷冻干燥法制备伊维菌素微胶囊包埋效果良好,且该微胶囊的光热稳定性良好。
译 名：
Study on Preparation and Characteristics of Microcapsule of Ivermectin
作 者：
LU Jing-xiu,TAN Wei,ZHAO Su-qing,ZHENG Guang-hao,YAO Min-jie,DING Qian(Faculty of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China)
关键词：
ivermectin microcapsule;HI-CAP-100;HPLC
摘 要：
Preparation,characterization and characteristics of microcapsule of ivermectin was studied.Microcapsule of ivermectin was prepared by the way of mixing ivermectin and HI-CAP-100 according to some proportion,emulsifying by ultrasound,then freeze-drying for 14 h.Product of microcapsule was characterized by FT-IR.Contents of ivermectin were detected by HPLC.At the same time,effect of light and temperature on microcapsule stability was studied.Results showed that its encapsulation ratio was up to 92.27% by the method of freeze drying.Characteristics of microcapsule were stable under continuous light 5 h and storage temperature of 30～60℃ 24 h.Preparation of microcapsule was successful on the basis of IR.Its encapsulation effect was good,and its light and temperature stability was good too.
导出引用
计量
文章访问数: 3
HTML全文浏览量: 0
PDF下载量: 0
所属期刊
