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Optimization of the extraction process of astragaloside IV from ASTRAGALI RADIX.

作  者:
Jingyu Duan;Yan Li;Huankai Yao;Sun YuanFeng;Li Dian;Qi We
单  位:
School of Pharmacy Xuzhou Medical College Xuzhou Jiangsu 221004 Chin;School of Pharmacy Xuzhou Medical College Xuzhou Jiangsu 221004 China
关键词:
astragaloside iv;astragali radix;ethanol concentration;the extraction process;extraction time;extraction time
摘  要:
[Objective] To optimize the extraction process of astragaloside IV from ASTRAGALI RADIX. [Method] Using TS-NS extraction and concentration industrial equipment to extract ASTRAGALI RADIX, effects of ethanol concentration, solid-liquid ratio, extraction time and extraction times on the yield of astragaloside IV were respectively investigated by uniform design experiment. Taking the content of astragaloside IV determined by HPLC-ELSD as index, the extraction process was optimized. [Result] The optimum extraction process of astragaloside IV from ASTRAGALI RADIX was: ethanol concentration of 80%, solid-liquid ratio of 1∶ 8 g/ml, extraction times of 3 and extraction time of 1 h. [Conclusion] The optimum process for extracting astragaloside IV was simple, reliable and more suitable for industrial production compared with the reported methods.
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