Position: Home > Articles > Genetic Control of Biosynthesis of Immunoglobulin in Teleost Fish
Journal of Anhui Agricultural Sciences
2005,33
(8)
1484-1485
鱼类免疫球蛋白生物合成的遗传控制研究综述
作 者：
丰培金;孙艳侠
单 位：
临沂师范学院农林科学学院;临沂师范学院实验与教育技术中心
关键词：
真骨鱼;IgM;IgD;遗传控制
摘 要：
真骨鱼重链IgM恒定区基因由CH1～CH44个外显子所编码,以IgM分泌型表达,其跨膜域由2个外显子所编码,它以淋巴细胞膜受体形式被利用,TM1外显子被直接剪接到CH3外显子,而不是在CH4外显子内,这种不寻常的剪接方式导致产生Cμ4区的膜IgM。真骨鱼IgD重链除包括分泌型或膜结合型的C末端外,这个重组分子还包括1个重组的可变区、μ链的第1个恒定区及7个恒定区。IgD(δ)重链基因恰好位于IgM(μ)基因下游,第1个恒定区μ外显子被剪切形成δ转录本。
译 名：
Genetic Control of Biosynthesis of Immunoglobulin in Teleost Fish
作 者：
FENG Pei-jin et al (College of Agriculture and Forestry Science, Linyi Normal University, Linyi, Shandong276003)
关键词：
Teleost fish; Immunoglobulin M; Immunoglobulin D; Genetic control
摘 要：
The immunoglobulin(IgM)heavychain constant region gene ofteleost fish contained four constant region domain- encodingexon(CH1to CH4) expressed in secreted form of the immunoglobulin, and two exons encoding the transmembrane (TM) domain utilized in the lymphocytemembrane receptor form of the immunoglobulin. TM1 exon was spliced directly to the CH3 exon, and not into a site within the CH4 exon. Thisunusual pattern of splicing, which produced a membrane heavy chain that lacked the C mμ4 domain. In addition to alternative secretory ormembrane-associated C termini, the heavy chain of IgD which was a novel complex chimeric molecule contained a rearranged variable domain,the first constant domain ofmμand seven constant domains encoded bydeta gene homolog. The IgDheavychain (delta)gene was downstreamofthe IgMheavychain (mμ)gene, the first constant mμexon was spliced intothe delta transcripts.
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