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当前位置: 首页 > 文章 > 噻虫嗪大鼠血浆中LC-MS/MS分析方法及其毒代动力学 农药 2014 (6) 418-420+465
Position: Home > Articles > LC-MS/MS Method for Quantifi cation of Thiamethoxam in Rat Plasma and Its Toxicokinetics Study Agrochemicals 2014 (6) 418-420+465

噻虫嗪大鼠血浆中LC-MS/MS分析方法及其毒代动力学

作  者：
林立红;于巍;庞亚男;孟庆贺;孙常松;李晓磊;段明郁
单  位：
沈阳化工研究院有限公司安全评价中心
关键词：
噻虫嗪;LC-MS/MS;毒代动力学;定量
摘  要：
[目的]建立大鼠血浆中噻虫嗪LC-MS/MS分析方法,单次灌胃给予大鼠2种剂量噻虫嗪进行毒代动力学的初步研究。[方法]使用Phenomenex Luna 5μm C18(2)色谱柱,采用ESI离子源,定量离子对为292.0/211.2。采用DAS软件拟合毒代动力学参数。[结果]低高剂量组的毒代动力学参数如下:tmax均为2 h,Cmax分别为71.8、389 mg/L,t1/2z分别为7.84、16.4 h,AUC(0-t)分别为1053、8 661 mg/(L·h)。[结论]该分析方法适用于大鼠血浆中噻虫嗪的测定。噻虫嗪在大鼠体内的毒代动力学过程具有非线性动力学性质。
译  名：
LC-MS/MS Method for Quantifi cation of Thiamethoxam in Rat Plasma and Its Toxicokinetics Study
作  者：
LIN Li-hong;YU Wei;PANG Ya-nan;MENG Qing-he;SUN Chang-song;LI Xiao-lei;DUAN Ming-yu;Safety Evaluation Center,Shenyang Research Institute of Chemical Industry;
关键词：
thiamethoxam;;LC-MS/MS;;toxicokinetics;;quantifi cation
摘  要：
[Aims]An LC-MS/MS method was developed for the determination of thiamethoxam in rat plasma.Toxicokinetics of thiamethoxam was researched by single oral administration with two doses.[Methods]A Phenomenex Luna 5 μm C(18)(2) column and ESI ion source were used,and quantitative ion pair was 292.0/211.2.The toxicokinetics parameters were fitted using DAS.[Results]The parameters of low and high dose were as follows:t(max) were all 2 h,C(max) were 71.8 and 389 mg/L,t(1/2z) were 7.84 and 16.4 h,AUC(0-t) were 1053 and 8661 mg/L·h,respectively.[Conclusions]The method was suitable for the analysis of concentrations of thiamethoxam in rat plasma.It was indicated the nonlinear toxicokinetics characteristic of thiamethoxam took place in the studied dose range.

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