Progress on Regulatory Effect of PASTA-eSTK on Bacteria

LIN Si-tong;LIU Xiao-lin;SUN Lei;SHA Jin-dan;LIU Yao-chuan;ZHANG De-xian;LIU Ming-chun;College of Animal Husbandry and Veterinary Medicine,Shenyang Agricultural University;

College of Animal Husbandry and Veterinary Medicine,Shenyang Agricultural University

PASTA-eSTKs;;protein phosphorylation;;bacterial cell division;;signal transformation

Bacteria possess a repertoire of versatile protein kinases modulating diverse aspects of their physiology by phosphorylating proteins and regulate the cell growth,virulence and drug resistance on various amino acids including histidine,cysteine,serine.eSTK is a phosphorylated protein located on the bacterial cell membrane and has an extracellular domain peculiar to the catalytic reaction zone and bacteria that are similar to the eukaryotic cells.This extracellular domain is called PASTA.In lots of recent reports suggesting that PASTA-eSTKs could be involved in the formation of compounds and life processes in bacteria including the cell wall synthesis,cell division,morphogenesis and developmental processes in spore.However,observations differ from one species to another suggesting that a general mechanism of activation of their kinase activity is unlikely and that species-specific regulation of cell division is at play.In this paper,we reviewed the regulation of eSTKs on bacterial cells by PASTA,and laid a foundation for the mechanism of protein kinase on bacterial cell division regulation and so on.