作 者：
王聪;肖怀;王立云;王玉梅;康绍龙;刘晓波
摘 要：
[目的]观察紫金龙总提取物对吗啡依赖小鼠戒断症状的影响。[方法]以连续递增剂量方式皮下注射盐酸吗啡建立吗啡依赖小鼠模型,灌胃不同剂量(150、300、600 mg/kg)的紫金龙总提取物40 min后,用纳络酮(4 mg/kg)腹腔注射催瘾。[结果]紫金龙总提物低、中、高剂量组对吗啡依赖小鼠戒断跳跃症状有抑制作用(P<0.05);对扭体症状具有显著抑制作用(P<0.01);对小鼠体重减少症状具有抑制作用(P<0.05),并且中、高剂量组效果显著(P<0.01);然而仅低、中剂量组对小鼠抓脸的戒断症状有抑制作用(P<0.05),其中中剂量组效果显著(P<0.01),而高剂量组与自然戒断组比较无显著性差异。[结论]紫金龙总提取物在一定程度上可缓解吗啡依赖小鼠戒断症状。
译 名：
Effects of Total Extract of Dactyicapnos scandens Hutch on Withdrawal Syndrome in Morphine-dependent Mice
作 者：
WANG Cong et al(College of Pharmacology Dali University,Dali,Yunnan 671000)
关键词：
Dactyicapnos scandens Hutch;Morphine;Dependence;Withdrawal syndrome
摘 要：
[Objective] The aim was to study the effects of total extract of Dactyicapnos scandens Hutch on the naloxone-precipitated withdrawal syndrome in morphine dependent mice.[Method] Mice were given increasing doses of morphine to produce a physical dependence.Then the withdrawal syndrome precipitated by naloxone was observed 40 min after total extract Dactyicapnos scandens Hutch were given.[Result] At the dose of 150,300 and 600 mg/kg,total extract Dactyicapnos scandens Hutch reduced jumping of mice(P<0.05),significantly inhibited writhing of mice(P<0.01) and inhibited body weight loss of mice(P<0.05) while the 300 and 600 mg/kg dose had significant inhibition(P<0.01).At the dose of 150 and 300 mg/kg,total extracts reduced scratch face action of mice(P<0.05).The moderate dose group had significant outcome(P<0.01).However,the dose of 600 mg/kg could not inhibit scratch face action compare with natural withdrawal team.[Conclusion] Total extract of Dactyicapnos scandens could significantly inhibit withdrawal syndrome in morphine dependent mice.
