中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 大蒜醇提液对小鼠离体小肠平滑肌运动的影响 新疆农业科学 2019 (11) 2133-2139
Position: Home > Articles > Effect of Alcohol Extract from Garlic on the Motility of Murine Small Intestinal Smooth Muscle in Vitro Xinjiang Agricultural Sciences 2019 (11) 2133-2139

大蒜醇提液对小鼠离体小肠平滑肌运动的影响

作  者：
阿迪莱·艾力;赵树林;李璐璐;孙小燕;余万里;郝智慧;赵红琼
单  位：
新疆农业大学动物医学学院
关键词：
大蒜;醇提液;小鼠;小肠;M-受体;KCl
摘  要：
【目的】研究大蒜醇提液对胃肠运动的影响,了解其可能的作用机制。【方法】用生物信号处理系统监测大蒜醇提液对小鼠离体小肠平滑肌运动的影响。【结果】2倍浓度递增(0.025%-0.4%)的大蒜醇提液剂量依赖性抑制小肠收缩幅度(P<0.05),但对收缩张力无影响(P> 0.05);大蒜醇提液抑制小肠收缩幅度的最效浓度为0.2%,小肠收缩幅度仅为用药前26%±7%(P<0.01);0.2%大蒜醇提液与M-受体激动剂氯贝胆碱或KCl联合用药对小肠收缩张力、收缩幅度、峰值和曲线下面积与这两种药物单独用药比差异均不显著(P> 0.05)。【结论】大蒜醇提液对小鼠离体小肠平滑肌的运动具有抑制作用,且该抑制作用可能同抑制胆碱能M-受体和阻止细胞内钾离子外流减少无关。
译  名：
Effect of Alcohol Extract from Garlic on the Motility of Murine Small Intestinal Smooth Muscle in Vitro
作  者：
Adilai Ali;ZHAO Shu-lin;LI Lu-lu;SUN Xiao-yan;YU Wan-li;HAO Zhi-hui;ZHAO Hong-qiong;College of Veterinary Medicine, Xinjiang Agricultural University;
关键词：
garlic;;alcohol extract;;mouse;;small intestine;;M-receptor;;KCI
摘  要：
【Objective】 To explore the effect of alcohol extract from garlic on gastrointestinal motility and to understand its possible mechanism of action. 【Method】In this experiment, the effect of alcohol extract from garlic on the motility of gastrointestinal smooth muscle in mice and its possible mechanism in vitro were monitored by biological signal processing system. 【Result】 The results showed that garlic alcohol extract with twice concentration(0.025%-0.4%) inhibited the contraction amplitude of small intestine(P< 0.05), but the contraction tension had not changed(P> 0.05); The maximum effective concentration of garlic was 0.2% which inhibited the contraction of intestine, and the contraction amplitude was 26% ± 7% of pre-administration(P< 0.01); 0.2% garlic combined with M-receptor agonist bethanechol chloride or KCl was not significantly different from bethanechol chloride or KCl alone in contraction tension, amplitude, peak and area under curve(P> 0.05). 【Conclusion】The present results indicate that alcohol extract from garlic inhibits the movement of isolated small intestine in mice, moreover, this inhibition effect may not be related to the inhibition of cholinergic M-receptors and the inhibition of decreased intracellular potassium ion outflow.

相似文章

导出引用
计量
文章访问数: 9
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46