Comparative Pharmacokinetics of Metabolite of Albendazole Oxide and Albendazole in Sheep Body

Qiu Yinsheng 1) Wang Daju 1) Zhou Zukun 2) Zhou Shiqi 1) Cao Jiyue 1) Yan Hanchi 2) Ling Sa 2) Cai Qinren 1) Li Tiejun 1) Wang Xu 1) ( 1) Huazhong Agricultural University,Wunhan 430070, China

albendazole oxide,albendazole,comparative pharmacokinetics,sheep, high performance liquid chromatography

Comparative pharmacokinetics of metabolite was investigated in eight healthy sheep(weighing 22～32kg) following oral administration of albendazole oxide and albendazole at 10 mg/kg body weight. HPLC analysis was used to determine albendazole(ABZ),albendazole oxide(ABSO) and its metabolites albendazole sulfone(ABSO\-2).Although no ABZ was detected in serum after the administration of the two compounds, metabolites ABSO and ABSO\-2 were found following the two treatments .There were no significant differences in the parameters of the area under the concentration time curve ( AUC ) for both metabolites following the two treatments. The AUC of ABSO and ABSO\-2 values were (29.34±11.38) and (21.98±5.88)μg/h·ml after treated with albendazole oxide,and were (28.86± 8.78 ) and (22.8±7.03)μg/h·ml after albendazole administration. The time of maximum serum concentration( T max ) of metabolite ABSO\-2 following administration of albendazole oxide was significantly shorter ( P <0.05) than that of albendazole. The values were (11.00±6.05) and (19.50±8.12) h respectively. The mean residence time (MRT) of metabolite ABSO after treated with albendazole oxide was also significantly shorter ( P <0.01) than that of albendazole. The values were ( 12.89 ±3.00) and (15.60±2.34)h respectively. Comparative studies revealed that there were no significant differences in the absorption amount for both metabolites; but there were differences in the absorption rates and elimination rates of metabolites in this study.\;