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CRISPR/Cas系统研发进展及展望

作  者:
王友华;邹婉侬;康宇立;唐巧玲;孙国庆
关键词:
CRISPR/Cas;系统分类;应用领域
摘  要:
成簇间隔的短回文重复序列(clustered regularly interspaced short palindromic repeat sequences,CRISPR)发现至今已有20年,但从第一个CRISPR/Cas基因编辑的成功应用至今,其在医药、农业、环保等领域短时间内即有了迅猛发展。归纳总结了CRISPR/Cas系统的分类和应用进展,阐述了该技术的研发现状、研究热点与发展态势,并对CRISPR/Cas技术的应用前景提出展望。
译  名:
Progress and Prospect of CRISPR/Cas System Research and Development
作  者:
WANG Youhua;ZOU Wannong;KANG Yuli;TANG Qiaoling;SUN Guoqing;The Ministry of Agriculture Key Laboratory for Agricultural Genomics(Beijing) ,Biotechnology Research Institute,Chinese Academy of Agricultural Sciences;
关键词:
CRISPR/Cas;;system classification;;application field
摘  要:
Clustered regularly interspaced short palindromic repeats( CRISPR) has been found for 20 years until now. But since the successful application of the first CRISPR/Cas gene editing,CRISPR achieves rapid development in the pharmaceutical,agriculture and environmental protection in a short time. This paper summarized the progress on classification and application of CRISPR/Cas system. We also reviewed the status,hotspot,trend of research and development in current field,and put forward the expectation for future of CRISPR/Cas technology application.

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