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Position: Home > Articles > Synergistic Effect of IFN-γ and Acetylcholine on Duodenal Myoelectric Activity in Rabbits Progress in Veterinary Medicine 2020 (5) 56-60

γ干扰素与乙酰胆碱对家兔十二指肠肌电活动的协同作用研究

作  者:
赵建帅;张金;辛先萌;武永杰;杜宜楠;郭雅茹;张莹利;徐永平
单  位:
西北农林科技大学动物医学院
关键词:
γ干扰素;乙酰胆碱;肌电活动指数;十二指肠;家兔
摘  要:
通过系统地研究γ干扰素-乙酰胆碱对家兔十二指肠肌电活动的协同作用规律,为探索IFN-γ影响十二指肠运动的作用机制及其临床应用提供参考依据。按正交试验设计分组,采用BL-420F生物机能试验系统实时监测不同剂量的IFN-γ联合乙酰胆碱对家兔十二指肠肌电活动的影响。在单因素IFN-γ的作用下,十二指肠肌电活动指数随着IFN-γ剂量的增加先升高后降低;而在氯化氨甲酰胆碱的作用下,随着IFN-γ剂量的增加,十二指肠肌电活动指数整体上呈现出逐渐下降的趋势,当且氯化氨甲酰胆碱的浓度越大,十二指肠肌电活动指数下降的幅度也越大。细胞因子IFN-γ可能是通过胆碱能神经这条途径发挥对十二指肠的调节作用,这是除经典内分泌调节、下丘脑-垂体-靶腺轴外,一种通过神经系统作用间接支配靶器官活动的神经传导作用模式。
译  名:
Synergistic Effect of IFN-γ and Acetylcholine on Duodenal Myoelectric Activity in Rabbits
作  者:
ZHAO Jian-shuai;ZHANG Jin;XIN Xian-meng;WU Yong-jie;DU Yi-nan;GUO Ya-ru;ZHANG Ying-li;XU Yong-ping;College of Veterinary Medicine,Northwest A&F University;
关键词:
IFN-γ ;;acetylcholine;;myoelectric activity index;;duodenum;;rabbits
摘  要:
To systematically study the synergistic effect of IFN-γon the electrical activity of duodenal muscle in rabbits,and to provide a reference for exploring the mechanism of IFN-γaffecting duodenal movement and its clinical application,according to the orthogonal experimental design grouping,the effects of different doses of IFN-γon the electrical activity of duodenum muscle in rabbits were monitored by BL-420 Fbiological function experiment system.Under the action of single factor IFN-γ,the duodenal myoelectric activity index increased first and then decreased with the increase of IFN-γdose;while under the action of carbachol,with the increase of IFN-γdose,the duodenal myoelectric activity index showed a gradual decline overall,and the greater the concentration of carbachol,the more the duodenal myoelectric activity index decreased.The cytokine IFN-γmay play a role in the regulation of the duodenum through the cholinergic nerve.This is a new type act on the mode of action that governs the neurotransmitter pathway of the target organ in addition to the classical endocrine regulation,hypothalamic-pituitary-target gland axis.

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