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当前位置: 首页 > 文章 > 维拉帕米对肉鸡肺动脉高压发生过程中肺动脉平滑肌细胞c-Fos表达的影响 畜牧兽医学报 2015,46 (8) 1432-1437
Position: Home > Articles > The Effect of Verapamil on the c-Fos Expression of Pulmonary Artery Smooth Muscular Cells in the Development of Pulmonary Hypertension in Broilers Induced by Low Ambient Temperature Chinese Journal of Animal and Veterinary Sciences 2015,46 (8) 1432-1437

维拉帕米对肉鸡肺动脉高压发生过程中肺动脉平滑肌细胞c-Fos表达的影响

作  者：
王建琳;乔健
单  位：
青岛农业大学动物科技学院;中国农业大学动物医学院
关键词：
肉鸡;肺动脉压;平滑肌细胞;c-Fos;维拉帕米
摘  要：
研究低温诱发肉鸡肺动脉高压过程中肺动脉平滑肌细胞c-Fos的表达情况,及钙拮抗剂维拉帕米对c-Fos表达和肺动脉压的影响,从而探讨肉鸡肺动脉高压的发生机制。180只AA肉鸡14日龄随机分为对照组、低温处理组和维拉帕米组,14~49日龄,每组每周随机取6只测定肺动脉压,取肺组织固定做石蜡组织切片进行c-Fos免疫组织化学染色分析。结果显示,低温处理1周后肉鸡肺动脉压明显升高(P<0.05),20~50μm肺动脉平滑肌细胞c-Fos表达在处理后1周开始明显升高,50~100μm肺动脉c-Fos表达在处理后2周开始明显升高(P<0.05),而维拉帕米组肉鸡肺动脉压和c-Fos的表达在相应的时间内较低温组明显降低(P<0.05)。结果表明肺动脉平滑肌细胞c-Fos在低温诱发的肉鸡肺动脉压升高的过程中表达增强,阻断钙通道可抑制肉鸡肺动脉平滑肌细胞c-Fos的过高表达和肺动脉压升高。
译  名：
The Effect of Verapamil on the c-Fos Expression of Pulmonary Artery Smooth Muscular Cells in the Development of Pulmonary Hypertension in Broilers Induced by Low Ambient Temperature
作  者：
WANG Jian-lin;QIAO Jian;College of Animal Science and Veterinary Medicine,Qingdao Agricultural University;College of Veterinary Medicine,China Agricultural University;
关键词：
broilers;;pulmonary arterial pressure;;smooth muscle cells;;c-Fos;;verapamil
摘  要：
The c-Fos expression of the pulmonary arterial smooth muscle cells in the development of the pulmonary hypertension in broilers induced by low ambient temperature and the effect of verapamil on c-Fos expression were dynamically studied.One hundred and eighty 14-day-old AA broilers were randomised into three groups,control group(21 ℃±1 ℃),low temperature group(10 ℃±1 ℃)and verapamil group(10 ℃±1 ℃,add 0.01% verapamil in drinking water).Then their pulmonary arterial pressures were measured;and the lungs of broilers were fixed to study the expression of c-Fos.The results showed that the pulmonary arterial pressure in low temperature group significantly higher than those in control group and verapamil group after exposure to low temperature one week(P<0.05),the expression of c-Fos in 20-50μm and 50-100μm pulmonary arteries in low temperature group were significantly higher than those in control group and verapamil group after exposure to low temperature one and two weeks respectively(P<0.05).The results suggested that the expression of c-Fos in pulmonary arteries were significantly increased and verapamil can prevent the high expression of c-Fos and the increase of pulmonary arterial pressure.

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