Position: Home > Articles > Optimization of Inclusion Technology for 6-Gingerol in RHIZOMA ZINGIBERIS
Journal of Anhui Agricultural Sciences
2011,39
(6)
3303-3304+3308
干姜中6-姜辣素包合工艺的优化
作 者：
傅秀娟;何兵;刘艳;王芳
单 位：
四川省泸州医学院药学院
关键词：
6姜-辣素;β-环糊精;包合物;研磨法;正交设计
摘 要：
[目的]优化干姜(RHIZOMA ZINGIBERIS)中6姜-辣素、β-环糊精包合物的制备工艺,提高干姜产品的稳定性。[方法]采用研磨法制备包合物;采用单因素试验结合正交设计法优化包合条件;采用高效液相色谱法(HPLC)进行含量测定,以包合率(0.6)、包合物收率(0.2)及包合物含6姜-辣素的百分数(0.2)加权评分为评价指标。[结果]最佳的包合条件为:干姜提取物浓缩至相对密度为1.08(25℃),加入2倍量水研磨1.0 h,干姜醇提液∶β-环糊精为1.5∶10.0(W/W)。[结论]该包合工艺合理可行,重复性好,包合效果好,可指导6姜-辣素-β-环糊精包合物的生产。
译 名：
Optimization of Inclusion Technology for 6-Gingerol in RHIZOMA ZINGIBERIS
作 者：
FU Xiu-juan et al (School of Pharmacy,Luzhou Medical College,Luzhou,Sichuan 646000)
关键词：
6-Gingerol;β-Cyclodextrin;Inclusion complex;Grinding method;Orthogonal design
摘 要：
[Objective] To optimize the inclusion technology for 6-gingerol in RHIZOMA ZINGIBERIS,so as to improve the stability of RHIZOMA ZINGIBERIS products.[Method] The inclusion complex was prepared by grinding method,and the inclusion process was optimized by orthogonal design combined with single factor test.In addition,content of 6-gingerol was determined by HPLC,and the processes was assessed with weight grade method using inclusion rate(0.6),yield(0.2) and the percentage of 6-gingerol in inclusion complex(0.2) as indices.[Result] The optimum inclusion processes were as follows: concentrating density of RHIZOMA ZINGIBERIS extract of 1.08(25℃),2 times the volume of water,grinding duration of 1.0 h,and ratio of extract weight to β-cyclodextrin weight of 1.5∶10.0.[Conclusion] The optimized inclusion process is reasonable,feasible,reproducible and efficient,which can be used for supervising the production of β-cyclodextrin-6-gingerol inclusion complex.
导出引用
计量
文章访问数: 9
HTML全文浏览量: 0
PDF下载量: 1
所属期刊
