Position: Home > Articles > Research Progress on Rspo1 Protein and Wnt Signaling Pathway and Their Roles in Sex Determination
Animal Husbandry and Feed Science
2015
(4)
50-52
Rspo1蛋白与Wnt信号通路及其在性别决定方面的研究进展
作 者：
刘田田
单 位：
中国海洋大学海洋生物遗传学与育种教育部重点实验室
关键词：
Rspo1蛋白;Wnt/β-catenin信号通路;性别决定
摘 要：
R-spondin(Rspo)蛋白家族是近些年新发现的重要分泌性蛋白家族,包括4个成员(Rspo1~4),该家族成员都具有4个保守结构域:N末端亲水的信号肽结构域、2~3个富含半胱氨酸的furin-like结构域、血小板反应蛋白结构域(TSP1)和C末端富含碱性氨基酸的基础结构域。Wnt信号通路是生物体内的重要通路之一,在生物体生长发育过程中发挥着至关重要的作用。Rspo1蛋白作为Rspo蛋白家族中的一员,是一个潜在的雌性决定因子,能够与Wnt配体协同作用激活Wnt/β-catenin信号通路,调控生物体的性别决定及其他生理功能。
译 名：
Research Progress on Rspo1 Protein and Wnt Signaling Pathway and Their Roles in Sex Determination
作 者：
LIU Tian-tian;Key Laboratory of Marine Genetics and Breeding, Ocean University of China,Ministry of Eeducation;
关键词：
Rspo1;;Wnt/β-catenin signaling pathway;;sex-determination
摘 要：
The R-spondin(Rspo) protein family is a newly found secretory protein family in recent years which include four family members(Rspo1 to Rspo 4). All the members in Rspo protein family contain four highly conserved domains: hydrophilic secretion signal peptide domain in N-terminal, two or three furin-like cysteine-rich domains, thrombospondin-type 1(TSP1)domain and amino acid-rich basic domain in C-terminal. Wnt signaling pathway is one of the significant pathways in organism which plays a crucial role in the process of growth and development. As a member of Rspo protein family, Rspo1 is a potential female-determination factor that can activate Wnt signaling pathway and regulate the sex-determination and other biological function of organism by cooperation with Wnt ligands.
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