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Position: Home > Articles > Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation Food Science and Human Wellness 2024 (3) 1201-1211

Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation

作者：

Dingwu Qu;Zhennan Gu;Saisai Feng;Leilei Yu;Fengwei Tian;Hao Zhang;Wei Chen;Qixiao Zhai

单位：

State

关键词：

Gut;commensals;Dextran;sulfate;sodium(DSS)colitis;Intestinal;barrier;IMMUNOREGULATION

摘要：

Inflammatory bowel disease(IBD)is a complex relapsing inflammatory disease in the gut and is driven by complicated host-gut microbiome interactions.Gut commensals have shown different functions in IBD prevention and treatment.To gain a mechanistic understanding of how different commensals affect intestinal inflammation,we compared the protective effects of 6 probiotics(belonging to the genera Akkermansia,Bifidobacterium,Clostridium,and Enterococcus)on dextran sulfate sodium(DSS)-induced colitis in mice with or without gut microbiota.Anti-inflammatory properties(ratio of interleukin(IL)-10 and IL-12)of these strains were also evaluated in an in vitro mesenteric lymph nodes(MLN)co-culture system.Results showed that 4 probiotics(belonging to the species Bifidobacterium breve,Bifidobacterium bifidum,and Enterococcus faecalis)can alleviate colitis in normal mice.The probiotic strains differed in regulating the intestinal microbiota,cytokines(IL-10,IL-1βand interferon(IFN)-γ),and tight junction function(Zonulin-1 and Occludin).By constrast,Akkermansia muciniphila AH39 and Clostridium butyricum FHuNHHMY49T1 were not protective.Interestingly,B.breve JSNJJNM2 with high anti-inflammatory potential in the MLN model could relieve colitis symptoms in antibiotic cocktail(Abx)-treated mice.Meanwhile,E.faecalis FJSWX25M1induced low levels of cytokines in vitro and showed no beneficial effects.Therefore,we provided insight into the clinical application of probiotics in IBD treatment.

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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation

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