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桑叶多糖对2型糖尿病大鼠GLUT4 mRNA表达的影响

作  者:
刘洪凤;韩智学;赵正林;王桂云;田丽梅
单  位:
牡丹江医学院生物化学教研室
关键词:
桑叶多糖;2型糖尿病;胰岛素抵抗;葡萄糖转运蛋白4
摘  要:
目的:探讨桑叶多糖(Mulberry Leaves Polysaccharides,MLP)对2型糖尿病(2-DM)大鼠脂肪组织葡萄糖转运蛋白4(GLUT4)基因表达的影响。方法:将Wistar大鼠随机分为正常对照组、模型组、桑叶多糖高、中、低剂量治疗组。用药12周后,RT-PCR检测GLUT4 mRNA基因表达水平。结果:桑叶多糖高、中、低剂量治疗组GLUT4 mRNA表达高于模型组。结论:桑叶多糖可上调2型糖尿病大鼠GLUT4 mRNA表达,从而实现其降血糖作用。
译  名:
Effect of Mulberry Leaves Polysaccharides on Insulin Resistance and Gene Expression of GLUT4 in Type 2 Diabetes Mellitus Rats
作  者:
LIU Hong-feng,HAN Zhi-xue,ZHAO Zheng-lin,WANG Gui-yun,TIAN Li-mei(Department of Biochemistry,Mudanjiang Medical College,Mudanjiang 157011,China)
关键词:
MLP;2-DM;IR;GLUT4 mRNA
摘  要:
【Objective】 To investigate the effect of mulberry leaves polysaccharides(MLP) on insulin resistance and the expression of GLUT4 mRNA of rats with type 2 diabetes.【Method】 The rats model with type 2 diabetes were induced by high calorie feeding and small dose injection of STZ.Wistar rats were randomly divided into the control group,model group and high,middle,low doses of MLP groups.The mRNA expression of GLUT4 was metered by RT-PCR at the end of 12 weeks.【Result】 The mRNA expression of GLUT4 gene increased in the high,middle and low doses of MLP groups.【Conclusion】 MLP could decrease insulin resistance by increasing mRNA expression of GLUT4 gene in 2-DM rats.

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