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Position: Home > Articles > One-pot Synthesis of 2-Hydroxybenzonitrile from Salicylaldehyde Modern Agrochemicals 2007,6 (3) 21-22+24

水杨醛一步法合成邻羟基苯甲腈

作  者:
陈强;廖文文;刘智凌
单  位:
湖南化工研究院国家农药创制工程技术研究中心;江苏宝灵化工股份有限公司;湖南师范大学化学化工学院
关键词:
邻羟基苯甲腈;水杨醛;一步法合成
摘  要:
以水杨醛为原料一步法生产邻羟基苯甲腈。61.5g(0.5mol)水杨醛、42g(0.6mol)盐酸羟胺和500mLN-甲基吡咯烷酮,110~115℃下反应5h,得产品邻羟基苯甲腈,摩尔收率91.2%,产品含量99%。
译  名:
One-pot Synthesis of 2-Hydroxybenzonitrile from Salicylaldehyde
作  者:
CHEN Qiang1, LIAO Wen-wen2, LIU Zhi-ling3 (1. Jiangsu Baoling Chemical Co., Ltd., Jiangsu Nantong 226006, China; 2. College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410082, China; 3. National Engineering Research Center for Agrochemicals, Hunan Reseach Institute of Chemical Industry, Changsha 410007, China)
关键词:
2-hydroxybenzonitrile; salicylaldehyde; one-pot synthesis
摘  要:
2-Hydroxybenzonitrile was preprared in high yield in a one-pot process by reacting salicyladehyde with hydroxylamine hydrochloride in N-methylpyrrolidone at 110 to 115℃ for 5 h. After purification ,the yield of the product is 91.2% and content 99%.

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