Position: Home > Articles > Pharmacokinetics of Miloxacin in the Culture Environment of Penaeus chinensis
Journal of Anhui Agricultural Sciences
2008,36
(24)
10480-10483
米诺沙星在中国对虾体内的代谢动力学及在养殖系统中的消除
作 者：
李娜;李健;王群
单 位：
上海水产大学生命科学与技术学院;中国水产科学研究院黄海水产研究所
关键词：
米诺沙星;中国对虾;养殖系统;药物代谢动力学
摘 要：
[目的]为米诺沙星在中国对虾养殖中的合理应用及环境安全提供理论依据。[方法]在水温21~22℃条件下,米诺沙星药饵以每天30 mg/kg虾体重连续投喂中国对虾5 d后,应用反相高效液相色谱法(RP-HPLC)研究米诺沙星在中国对虾体内的代谢动力学以及米诺沙星在水环境及底泥环境中的分布和消除。[结果]试验结果表明:试验数据经3P87药动学软件分析,米诺沙星在中国对虾各组织中的代谢符合开放性二室模型。药饵给药后,大部分药物经饵料被对虾摄食,小部分的米诺沙星进入环境中,随着时间的推移,米诺沙星在水环境中的含量逐渐衰减,在同一时间时距离表层水面10 cm处与距离底泥表面10 cm处的水样样品含量在0.05水平无差异。水体中的米诺沙星的含量-时间拟合曲线回归方程为Y=-0.002 9lnX+0.008 6。[结论]底泥对米诺沙星有吸附作用,米诺沙星有向底泥转移的趋势。
译 名：
Pharmacokinetics of Miloxacin in the Culture Environment of Penaeus chinensis
作 者：
LI Na et al(College of Aqua-life Science and Technology,Shanghai Fisheries University,Shanghai 200090)
关键词：
Miloxacin;Penaeus chinensis;Culture environment;Pharmacokinetics
摘 要：
[Objective] The research aimed to provide theoretical basis for the reasonable application and environmental security of miloxacin used in Penaeus chinensis.[Method] Shrimps were kept in experimental tanks with aerated tapwater of 21-22 ℃.The shrimps were fed medicated feed by oral administration.The dosage of miloxacin(MLX) was 30 mg/kg body weight per day for 5 consecutive days.Study on pharmacokinetics of MLX in shrimp and distribution and elimination of MLX in mariculture environment of water and sediment was carried out by RP-HPLC.[Result] By 3P87,the elimination of MLX accorded with open two-compartment model.In the experiment,elimination of MLX was slow.Meanwhile,there was difference between the concentrations of surface and bottom,but the difference was not significant.The concentration-time curve of MLX in water was Y=-0.002 9ln X+0.008 6.[Conclusion] Sediment could adsorb miloxacin and miloxacin had the trend to shift into sediment.
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