Position: Home > Articles > Synthesis of Haloxyfop-P-methyl
Modern Agrochemicals
2016,8
(3)
23-24+28
高效氟吡甲禾灵的合成
作 者：
王述刚;蒋剑华;陈新春;薛谊
单 位：
南京红太阳生物化学有限责任公司
关键词：
(R)-(+)-2-(4-羟基苯氧基)丙酸甲酯;高效氟吡甲禾灵;合成
摘 要：
研究了以(R)-(+)-2-(4-羟基苯氧基)丙酸甲酯和2,3-二氯-5-三氟甲基吡啶为原料合成高效氟吡甲禾灵的后醚化方法。通过对溶剂、反应时间、反应温度等反应影响因素的研究,得出最佳合成条件。以N,N-二甲基乙酰胺为溶剂,碳酸钾为缚酸剂,在85℃下反应6 h以上,高效氟吡甲禾灵的收率为97.2%,e.e.值为98.4%。此方法具有产品成本更低、质量更好的优势。
译 名：
Synthesis of Haloxyfop-P-methyl
作 者：
WANG Shu-gang;JIANG Jian-hua;CHEN Xin-chun;XUE Yi;Nanjing Redsun Biochemical Co.,Ltd.;
关键词：
(R)-(+)-2-(4-hydroxyphenoxy)propanoate;;haloxyfop-P-methyl;;synthesis
摘 要：
Ha loxyfop-P-meth yl was synthesized by reaction of 2,3-dichlor-5-trifluoromethylpyridine and(R)-(+)-2-(4-hydroxyphenoxy)propanoate.The influences on reaction yield by solvent,reaction time and temperature were investigated.Thus the optimum process for the reaction was performed at the temperature of 85℃ over the period of 6 h by using DMAC as solvent,and with potassium carbonate as base,resulting in 97.2% of yield with 98.4% value of e.e.
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