Position: Home > Articles > The Synthesis of N-Methyl-N-isopropyl Sulfonamide
Agrochemicals
2013,52
(10)
721-722，725
N-甲基-N-异丙基胺基磺酰胺的合成
作 者：
汤阿萍;廖道华;牛纪凤;解西军;高倩;李爱军;陈立鹏
单 位：
华东理工大学药学院
关键词：
N-甲基-N-异丙基磺酰胺;苯嘧磺草胺;合成
摘 要：
[目的]旨在探索并优化出一条适合工业化生产N-甲基-N-异丙基胺基磺酰胺的工艺路线。[方法]氯磺酰异氰酸酯与甲酸水溶液反应得到氨基磺酰氯,然后与N-甲基-N-异丙基胺反应得到目标产物N-甲基-N-异丙基胺基磺酰胺。[结果]反应总收率为62.7%,产物与中间体经1H NMR、MS等进行了表征。[结论]该路线收率较高,操作简便,可作为工业生产路线。
译 名：
The Synthesis of N-Methyl-N-isopropyl Sulfonamide
作 者：
TANG A-ping;LIAO Dao-hua;NIU Ji-feng;XIE Xi-jun;GAO Qian;LI Ai-jun;CHEN Li-peng;Pharmacy School, East China University of Science and Technology;
关键词：
N-methyl-N-isopropyl sulfonamide;;saflufenacil;;synthesis
摘 要：
[Aims] This article aims to explore and optimize a reasonable synthesis route of N-methyl-N-isopropyl sulfonamide on industrial scale.[Methods] Amino sulfonyl chloride was synthesized from chloriosulfonyl isocyanate and aqueous formic acid,then reacted with N-methy-N-isopropyl amine to get the target product.[Results] The total yield was 62.7%.The products and intermediates were determined by1H NMR and MS and so on.[Conclusions] The yield is improved and the process is simplified,which can be used in industry.
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