Effect and Safety of Tangerine Peel Active Principle Acetate on Animals of Infected Mite

ZHANG Zuo-xin, WU Yong-kui, Qi Chao, YAN Zhang-nian, ZHANG Li-shu, CAI Hui ( The Military Veterinary Institute, Quartermaster University of PLA , Changchun, Jilin 130062, China)

tangerine peel active principle acetate; mite; treatment; safety

Several derivatives were achieved by the structure modifications of tangerine peel active principle , in which the tangerine peel active principle acetate (TPAPA) has better effect of mite-killing. Treatment tests were carried out using TPAPA as 1% , 2% latex or 0.1% wiper. Mice, dogs, rabbits, and deer were treated with those agents 2 times at 1 week interval. The results showed that the clinical symptoms (such as itch, hair loss) of those animals disappeared, the infected skins softened, the body weights increased, and live mites were not found in the microscope check. Similarly, sika deer were recovered when 5 % TPAPA penetrating agent were treated 3 times at 1 week interval. Different concentrations of TPAPA latex were used to conduct the safety test. Mice in different groups were immersed in latex for 1 minute. The results showed that mice did not appear any abnormal activities with 0.1% latex, while light intoxication appeared with 1 % latex, but all recovered in 5 hours. When the concentration was increased to 4 % , middle intoxications arose, but all mice recovered in 24 hours except one died in 5 hours. It is suggested that TPAPA is a good mite-killing agent, and has a wide safety spectrum.