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当前位置: 首页 > 文章 > TGF-β信号通路在鱼类性别决定与分化中的作用 水产学报 2020 (1) 166-177
Position: Home > Articles > Role of TGF-β signaling pathway in sex determination and differentiation in fish Journal of Fisheries of China 2020 (1) 166-177

TGF-β信号通路在鱼类性别决定与分化中的作用

作  者：
龙娟;郑树清;王晓双;张帅;王德寿
单  位：
西南大学生命科学学院淡水鱼类资源与生殖发育教育部重点实验室
关键词：
鱼类;TGF-β信号通路;性别决定基因;性控育种
摘  要：
脊椎动物性别分化和性腺发育的分子机制保守,但不同类群的最上游的性别决定基因却大不相同,尤其是鱼类,其性别决定基因表现出明显的多样性。性别决定包括环境性别决定和遗传性别决定,环境性别决定主要受温度、光照、激素和pH等的影响,而遗传性别决定一般由位于性染色体上的性别决定基因决定。转化生长因子-β(transforming growth factorβ, TGF-β)信号通路参与介导了多种生物学过程,近年来很多研究表明,鱼类有多个性别决定基因都是TGF-β信号通路的成员,且该信号通路对于鱼类的性别分化也有重要的作用。本文总结了鱼类已报道的性别决定基因或候选基因,详细综述了TGF-β信号通路在鱼类性别决定与分化中的各种功能,并探讨了该信号通路参与鱼类性别决定的可能机制,这对认识TGF-β信号通路在鱼类性别决定、分化中的作用和性控育种有重要意义。
译  名：
Role of TGF-β signaling pathway in sex determination and differentiation in fish
作  者：
LONG Juan;ZHENG Shuqing;WANG Xiaoshuang;ZHANG Shuai;WANG Deshou;Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University;
关键词：
fish;;TGF-β signaling pathway;;sex-determination gene;;sex control
摘  要：
Although the molecular mechanisms of sex differentiation and gonad development are conserved across vertebrates, the most upstream sex-determining genes are quite different for different groups, especially for fish,whose sex-determining genes show obvious diversity. There are two types of sex determination in vertebrates, i.e.environmental sex determination and genetic sex determination. Environmental sex determination is mainly affected by temperature, light, hormones and pH, while genetic sex determination is generally determined by sexdetermining gene located on sex chromosome. Transforming growth factor-β(TGF-β) signaling pathway is involved in a variety of biological processes. In recent years, many studies have shown that multiple sexdetermining genes are members of the TGF-β signaling pathway, and this signaling pathway also plays an important role in sex differentiation of fishes. This paper summarizes the sex-determining genes or candidate genes that have been discovered and reported in fishes, and reviews in detail the role of TGF-β signaling pathway involved in sex determination and differentiation in fishes. We also discussed the mechanism of TGF-β signaling pathway involved in sex determination, which is important in understanding the role of TGF-β signaling pathway in fish sex determination, differentiation and sex control.

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