中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 肌注马波沙星在犊黄牛体内的药动学及半体内抗菌后效应研究 畜牧兽医学报 2015,46 (11) 2078-2084
Position: Home > Articles > Pharmacokinetic of Marbofloxacin in Infancy Yellow Cattle after Single Intramuscular Administrations and ex vivo the Post-antibiotic Effects Chinese Journal of Animal and Veterinary Sciences 2015,46 (11) 2078-2084

肌注马波沙星在犊黄牛体内的药动学及半体内抗菌后效应研究

作  者：
曹长福;孙美珍;卢燕;曾庆林;刘伟;曾振灵
单  位：
华南农业大学兽医学院/国家兽药残留基准实验室
关键词：
马波沙星;犊黄牛;药代动力学;多杀性巴氏杆菌;抗菌后效应
摘  要：
旨在研究单次肌内注射马波沙星在犊黄牛体内的药动学及马波沙星对多杀性巴氏杆菌的抗菌后效应。选用5头健康犊黄牛按体重以2mg·kg-1的剂量给药,用高效液相色谱法测定马波沙星的血药浓度,使用WinNolin6.2药物动力学软件提供的非房室模型处理血药浓度-时间数据。并测定马波沙星对多杀性巴氏杆菌在预定时间点收集血清中的抗菌后效应(PAE)。马波沙星在犊牛血清中的主要药动学参数:Cmax2.04μg·mL-1、Tmax0.83h、AUC15.03h·μg·mL-1、AUMC138.67h·h·μg·mL-1、MRT9.17h、t1/2β9.00h、Vd1.80L·kg-1、CL/F0.14L·(h·kg)-1。当血清中马波沙星浓度大约在2MIC、4MIC、8MIC时,其PAE的值分别为1.90、2.65、3.50h。结果表明,犊牛肌注马波沙星后,吸收相对较为迅速,分布广泛,消除缓慢;对多杀性巴氏杆菌在血清中具有较长的抗菌后效应,且与暴露药物呈明显的浓度依赖性。
译  名：
Pharmacokinetic of Marbofloxacin in Infancy Yellow Cattle after Single Intramuscular Administrations and ex vivo the Post-antibiotic Effects
作  者：
CAO Chang-fu;SUN Mei-zhen;LU Yan;ZENG Qing-lin;LIU Wei;ZENG Zhen-ling;National Reference Laboratory of Veterinary Drug Residues (SCAU),College of Veterinary Medicine,South China Agricultural University;
关键词：
marbofloxacin;;infancy yellow cattle;;pharmacokinetic;;Pasteurella multocida;;post-antibiotic effects
摘  要：
This experiment was conducted to study the pharmacokinetics parameters of marbofloxacin after single intramuscular administration in infancy yellow cattle and the Post-antibiotic effects(PAE)of marbofloxacin against Pasteurella multocida in serum.Marbofloxacin was administered to 5healthy infancy yellow cattle at a dose of 2mg·kg-1 of body weight,the concentrations of marbofloxacin in serum were determined by high-performance liquid chromatography and marbofloxacin concentration-time data in serum were analyzed using non-compartmental analysis of WinNolin6.2programme.Furthermore,PAE of marbofloxacin against Pasteurella multocida were tested in serum collected at predetermined time point.The main pharmacokinetic parameters intramuscularly were as follows:Cmax=2.04μg·mL-1,Tmax=0.83 h,AUC=15.03h·μg·mL-1,AUMC =138.67h·h·μg·mL-1,MRT =9.17 h,t1/2β=9.00 h,Vd=1.80L·kg-1,CL/F= 0.14L·(h·kg)-1.The PAE of marbofloxacin against P.multocida at the concentration levels of 2MIC,4MIC,8MIC in serum were 1.90,2.65,3.50 hrespectively.It was noted that marbofloxacin was relatively rapidly absorbed,widely distributed and slowly eliminated after intramuscular administration.The PAE of marbofloxacin against P.multocidain serum wasobviously prolonged and dependent on concentration.

相似文章

导出引用
计量
文章访问数: 24
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46