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当前位置: 首页 > 文章 > 早期肠内营养加微生态制剂对重症急性胰腺炎患者疗效的影响 中国食物与营养 2018 (006)
Position: Home > Articles > 早期肠内营养加微生态制剂对重症急性胰腺炎患者疗效的影响 Food and Nutrition in China 2018 (006)

早期肠内营养加微生态制剂对重症急性胰腺炎患者疗效的影响

作  者：
赫为;倪海伦
关键词：
肠内营养;微生态制剂;重症急性胰腺炎
摘  要：
目的:探讨早期肠内营养加微生态制剂对重症胰腺炎患者临床疗效、炎症指标及酶学指标的影响.方法:选取165例诊断为重症急性胰腺炎的患者,按就诊先后顺序分为对照组和观察组,对照组给予早期肠内营养,观察组给予早期肠内营养加微生态制剂,选取治疗后1、2w为观察时间点,比较两组患者的临床疗效、胃肠功能恢复情况,比较治疗前后血清白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)水平变化情况,比较治疗前后血清淀粉酶、血清脂肪酶、血清乳酸脱氢酶(LDH)及感染发生率.结果:观察组患者的临床疗效优于对照组,胃肠功能显著优于对照组,差异具有统计学意义(P<0.05),观察组患者的血清IL-6、TNF-α、CRP较对照组明显降低,差异具有统计学意义(P<0.05),观察组患者的血清淀粉酶、血清脂肪酶、LDH水平较对照组明显降低,差异具有统计学意义(P<0.05),观察组患者感染发生率明显低于对照组,差异具有统计学意义(P<0.05).结论:重症急性胰腺炎患者治疗早期,在肠内营养支持基础上加用微生态制剂能够明显降低患者炎症指标及相关酶学指标水平,且感染发生率明显降低,具有重要的临床意义.
作  者：
HE Wei;NI Hai-lun;Department of Emergency,Second People's Hospital;Department of 3rd Geriatrics,Second People's Hospital;
单  位：
HE Wei%NI Hai-lun%Department of Emergency,Second People's Hospital%Department of 3rd Geriatrics,Second People's Hospital
关键词：
enteral nutrition;;probiotics;;severe acute pancreatitis
摘  要：
Objective To investigate the effect of early enteral nutrition combined with probiotics on the clinical efficacy,inflammation and enzymology of severe acute pancreatitis. Method Totally 165 patients who were diagnosed as severe acute pancreatitis were divided into a control group and an observation group. The control group was given early enteral nutrition,and the observation group was given early enteral nutrition plus probiotics. After treatment,1 w and 2 w were selected to be the time point. The clinical efficacy and recovery of gastrointestinal function were compared between the two groups. Serum levels of interleukin-6( IL-6),tumor necrosis factor( TNF-α),and Creactive protein( CRP) were compared before and after treatment. Serum amylase,serum lipase,serum lactate dehydrogenase( LDH),and incidence of infection were compared before and after treatment. Result The clinical efficacy of the observation group was better than that of the control group,and the gastrointestinal function was significantly better than that of the control group. The serum IL-6,TNF-α,and CRP were significantly lower in the observation group than in the control group. Serum amylase,lipase and LDH levels were significantly lower in the observation group than in the control group( P < 0. 05). The incidence of infection in patients was significantly lower than that in the control group,and the difference was statistically significant( P < 0. 05). Conclusion In the early stage of treatment of patients with severe acute pancreatitis,the use of probiotics on the basis of enteral nutrition can significantly reduce the level of inflammatory markers and related enzymatic indicators,and the incidence of infection is significantly reduced,which has important clinical significance.

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