当前位置: 首页 > 文章 > 硒对小鼠血清中细胞因子水平的调控作用研究 中国畜牧兽医 2007,28 (6) 99-101
Position: Home > Articles > Effect of Se on Levels of IL-2,IL-6 and TNF-α in Murine Serum China Animal Husbandry & Veterinary Medicine 2007,28 (6) 99-101

硒对小鼠血清中细胞因子水平的调控作用研究

作  者:
荔霞;刘永明;齐志明;孟嘉仁;刘世祥;李建喜
单  位:
中国农业科学院兰州畜牧与兽药研究所
关键词:
硒;细胞因子;白细胞介素;肿瘤坏死因子;小鼠
摘  要:
通过给小鼠灌胃Na2SeO3,观察了0.025、0.05和0.1 mg/kg剂量的硒被应用后对小鼠血清中细胞因子IL-2、IL-6和TNF-α水平的影响,结果表明,硒能明显降低正常小鼠血清中的IL-2及TNF-α水平,且呈剂量依赖关系;对IL-6水平则有显著的升高作用,即呈正相关。该结果提示,微量元素硒对细胞因子水平有显著的调控作用。
译  名:
Effect of Se on Levels of IL-2,IL-6 and TNF-α in Murine Serum
作  者:
LI Xia,LIU Yong-ming,QI Zhi-ming,MENG Jia-ren,LIU Shi-xiang,LI Jian-xi(Lanzhou Institute of Animal Sciences and Veterinary Pharmaceutics of CAAS,Lanzhou 730050,China)
关键词:
Se;cytokines;IL-2;IL-6;TNF-α;mice
摘  要:
Changes of levels of IL-2,IL-6 and TNF-α in sera of mice were observed after the mice were treated with different doses Se of 0.025 mg/kg,0.05 mg/kg and 0.1 mg/kg respectively.Results were as follows.Se had functions to decrease the level of IL-2 in a dose dependent manner and lower the level of TNF-α significantly,and on the contrary the level of IL-6 significantly.The results showed that Se can enhance immune functions and adjust the levels of Cytokines in mice.

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