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当前位置: 首页 > 文章 > 富硒沼泽红假单胞菌G3菌与牛初乳复配改善小鼠免疫功能的作用研究 食品科学 2010,31 (21) 373-377
Position: Home > Articles > Combined Effect of Bovine Colostrumson and Selenium-enriched Rhodopseudomonas palustris G3 on Immune Function in Mice FOOD SCIENCE 2010,31 (21) 373-377

富硒沼泽红假单胞菌G3菌与牛初乳复配改善小鼠免疫功能的作用研究

作  者：
杨启银;王家芳;贾秉晟;管海华;刘青
单  位：
南京师范大学生命科学学院
关键词：
硒;牛初乳;沼泽红假单胞菌;环磷酰胺;免疫功能
摘  要：
目的:探讨富硒沼泽红假单胞菌G3菌(简称富硒G3菌)与牛初乳复配对小鼠免疫功能的影响。方法:将富G3菌与牛初乳复配形成富硒牛初乳,用环磷酰胺构建小鼠免疫低下模型,对免疫低下小鼠灌胃富硒G3菌、牛初乳和富硒牛初乳,50d后测定各组小鼠脏器指数、白细胞数、T淋巴细胞阳性率、血清SOD酶活性、全血GSH-Px活性,同时计算平均每日进食饲料质量与体质量增加量的比值。结果:富硒G3菌、牛初乳、富硒牛初乳均能提高免疫低下小鼠对饲料的利用率,能提高免疫低下小鼠SOD、GSH-Px活性、白细胞数和T淋巴细胞阳性率,其中富硒牛初乳高剂量组效果最为明显,说明富硒牛初乳高剂量组能显著增强小鼠的免疫功能。
译  名：
Combined Effect of Bovine Colostrumson and Selenium-enriched Rhodopseudomonas palustris G3 on Immune Function in Mice
作  者：
YANG Qi-yin1,2,3,WANG Jia-fang1,JIA Bing-sheng1,GUAN Hai-hua1,LIU Qing1 (1.College of Life Science,Nanjing Normal University,Nanjing 210046,China ;2.Nanjing Engineering and Technology Research Center for Microbiology,Nanjing 210046,China ;3.Jiangsu Engineering and Technology Research Center for Microbial Resources,Nanjing 210046,China)
关键词：
selenium;bovine colostrumson;Rhodopseudomonas palustris;cyclophosphamide;immunization
摘  要：
In order to investigate the effect of selenium-enriched bovine colostrumson on immune function of immunodepressed mice induced by cyclophosphamide,selenium-enriched Rhodopseudomonas palustris G3 (hereinafter called selenium-enriched G3) was mixed with bovine colostrumson to prepare selenium-enriched bovine colostrumson.The immunodepressed mice were treated with selenium-enriched G3,bovine colostrumson and selenium-enriched bovine colostrumson,respectively.The administration was carried out once a day for 47 successive days after 3 days of adaptive feeding,and organ index,white blood cell number,T-cell population,the contents of SOD and GSH-Px in blood,and feed/gain ratio of mice were determined at the end of the administration.Results indicated that selenium-enriched G3,bovine colostrumson and selenium-enriched bovine colostrumson could increase the utilization efficiency of diet,enhance the activities of SOD and GSH-Px in blood,and improve mouse immune function.Compared with the control group,the selenium-enriched bovine colostrumson exhibited best improved immune at the high dosage.

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