当前位置: 首页 > 文章 > 芳香烃受体调控肠道炎症的研究进展 动物营养学报 2018 (12) 4776-4785
Position: Home > Articles > Research Progress of Aryl Hydrocarbon Receptor in Regulating Intestinal Inflammation Chinese Journal of Animal Nutrition 2018 (12) 4776-4785

芳香烃受体调控肠道炎症的研究进展

作  者:
李成良;齐广海;彭鹏;方热军
单  位:
湖南农业大学动物科技学院;中国农业科学院饲料研究所农业部饲料生物技术重点开放实验室
关键词:
芳香烃受体;配体;免疫调控;炎症性肠病
摘  要:
芳香烃受体(AhR)是一种需配体激活的转录因子,对环境毒素、机体异物质代谢和免疫调节等具有重要作用。近年研究发现,AhR是参与免疫调控的关键因子,其对炎症性肠道疾病(IBD)的调控已成为当前研究热点。本文综述了AhR结构、配体、信号传导通路及AhR参与调控肠道炎症的最新研究进展,为治疗IBD提供新的思路。
译  名:
Research Progress of Aryl Hydrocarbon Receptor in Regulating Intestinal Inflammation
作  者:
LI Chengliang;QI Guanghai;PENG Peng;FANG Rejun;College of Animal Science and Technology,Hunan Agricultural University;Feed Research Institute,Chinese Academy of Agricultural Sciences,Key Laboratory of Feed Biotechnology of Ministry of Agriculture;
单  位:
LI Chengliang%QI Guanghai%PENG Peng%FANG Rejun%College of Animal Science and Technology,Hunan Agricultural University%Feed Research Institute,Chinese Academy of Agricultural Sciences,Key Laboratory of Feed Biotechnology of Ministry of Agriculture
关键词:
aryl hydrocarbon receptor;;ligands;;immunomodulatory;;inflammatory bowel disease
摘  要:
The aryl hydrocarbon receptor( AhR) is a transcription factor activated by synthetic ligands,and has important role on environmental toxins,organism metabolism and immunomodulatory. It has recently reported that AhR is a key factor in immune regulation,AhR regulating the inflammatory bowel disease( IBD)has become hot topic in current research. This article reviews the latest research on structure,ligand and signal transduction pathway of AhR and AhR regulating the intestinal inflammation,and provide newideas for cure the IBD.

相似文章

计量
文章访问数: 49
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊