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伊维菌素HP-β-CD包合工艺的优化

作  者:
张海亮;薛芬;李引乾;曹光荣;梅雪洁;庞利娜;黄冻;王婷;赵力;刘阳
单  位:
西北农林科技大学动物医学院
关键词:
伊维菌素;羟丙基-β-环糊精;包合物;正交试验
摘  要:
本文采用L9(34)正交试验,以伊维菌素利用率和增容倍数为指标,优选出伊维菌素-羟丙基-β-环糊精包合工艺的最佳条件。主要参数:伊维菌素与羟丙基-β-环糊精的物质量之比1∶3,包合时间2 h,研磨温度55℃。羟丙基-β-环糊精研磨时间是影响伊维菌素包合效果的主要因素。本试验为伊维菌素新制剂开发和临床应用提供试验依据。
译  名:
Optimization for preparation process of ivermectin enveloped with hydroxypropyl-β-cyclodextrin
作  者:
ZHANG Hai-liang,XUE Fen,LI Yin-qian,CAO Guang-rong,MEI Xue-jie,PANG Li-na,HUANG Dong,WANG Ting,ZHAO Li,LIU Yang(College of Veterinry Medicine,Northwest A & F University,Yangling 712100,China)
关键词:
ivermectin;hydroxypropyl-β-cyclodextrin;compound;orthogonal design
摘  要:
This article investigated an optimum process for enclosing ivermectin into hydroxypropyl-β-cyclodextrin by an orthogonal design of L9(34) based on the indexes of the utilization and the inclusion.And the best process technology was as follows: the ratio between ivermectin and hydroxypropyl-β-cyclodextrin was 1∶3(mol/mol);enclosing temperature was 55 ℃;enclosing time was 2 hours.Consumption of HP-β-Cyclodextrin plays an adominant role in inclusion efficiency.The findings apply a trial base for the development of new formulations of ivermectin.

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