Position: Home > Articles > Acute Toxicity of Anti-Lympholeukemic Extract from Tephroseris kirilowii Turcz. Holub
Progress in Veterinary Medicine
2004,25
(2)
92-93
狗舌草抗淋巴性白血病有效部位的急性毒性
作 者：
陈进军;孔庆波;王建华;冯平;弥胜利;史志诚
单 位：
中国刑警学院警犬技术系;西北农林科技大学动物科技学院;陕西省农业厅
关键词：
抗淋巴性白血病有效部位;LD_(50);急性毒性;狗舌草;小鼠
摘 要：
利用体重 19～ 2 2 g的 BAL B/ c-C雌性小鼠 ,通过腹腔注射 ,从急性半数致死量 L D50 和供试鼠的临床表现等方面 ,检查了狗舌草 60 %乙醇提取物冻干粉的急性毒性。结果发现 ,狗舌草 60 %乙醇提取物对雌性 BAL B/ c-C小鼠腹腔注射的 LD50 为 ( 791.2 2± 170 .17) mg/ kg,95 %可信限为 63 9.15～ 979.49m g/ kg。急性死亡小鼠 (剂量达到 3 3 6.11mg/ kg以上 )在死前表现四肢抽搐 ,盲目运动 ,呼吸急促 ,翘尾 ;未死亡的小鼠表现食欲减退 ,反应迟钝 ,在随后的长期饲养中 ,临床表现逐步恢复正常
译 名：
Acute Toxicity of Anti-Lympholeukemic Extract from Tephroseris kirilowii Turcz. Holub
作 者：
CHEN Jin-jun~(1,2),KONG Qing-bo~3,WANG Jian-hua~1,FENG Ping~1,MI Sheng-li~1,Zhi-cheng SHI~4 (1.College of Animal Sciences and Techndogy Northwest Sci-Tech University of Agriculture & Forestry,Yangling,Shaanxi,712100,China; 2.Dept. of Animal Sciences,Zhanjiang Ocean University, Zhanjiang,Guangdong,524088,China; 3.Dept.of Police Dog Sci-Tech,Chinese College of Criminalistic Police, Shenyang,Liaoning,110034,China; 4.Agricultural Administration Bureau of Shaanxi Province,Xi'an,Shaanxi,710003,China)
关键词：
anti-lympholeukemic extract;LD_(50);acute toxicity; Tephroseris kirilowii Turcz. Holub;mouse
摘 要：
A range of BALB/c-C mice with 19～22g body weight were intraperitoneally administered with anti-lympholeukemic extract from Tephroseris kirilowii Turcz. Holub to measure the LD_(50) and acute toxicity of the extract. The LD_(50) measured in this experiment was 791.22±170.17 mg/kg,with the 95% confidence limit of 639.15～979.49 mg/kg. The acutely dying mice, with dosage 336.11 mg/kg, showed some signs such as twitching limbs, blind movement,puffing and raising tail. And the survivors recovered gradually from anorexia and dullness.
导出引用
计量
文章访问数: 12
HTML全文浏览量: 0
PDF下载量: 0
所属期刊
