The Effect of Mebendazole on CAT Activities of the Yellow River Carp

GUO Guo-jun;GONG Fei-long;TANG Guo-pan;XU Wen-yan;QIN Gai-xiao;QI Zi-xin;Henan University of Animal Husbandry and Economy;Zhengzhou Aquatic Product Technology Promotion Department;

Yellow River carp(Cyprinus carpio L. var. haematopterus Temminck et Schlegel);;mebendazole;;CAT activities;;gill;;liver;;kidney

To investigate the toxic mechanism of mebendazole in Yellow River carp(Cyprinus carpio L. var. haematopterus Temminck et Schlegel),the method of static water contact exposure was used to study the effects of mebendazole on Catalase(CAT) activities in gill,liver and kidney of Yellow River carp with different concentrations,i.e.0,0.1,0.2,0.4,0.6 mg/L,respectively, and different action times,i.e.24,72,120,168 hours,respectively. The results showed that mebendazole had obvious inducing effect on the CAT activities of common carp with certain dose-response and time-response,and along with the increase of exposure concentration and time,the CAT activities increased firstly and then decreased. Especially,after exposure for 72 h,the effects of each treatment concentrations on the CAT activities of gill,liver pancreas and kidney of the Yellow River carp reached a very significant level. CAT activities could be a toxicity indicator of and the target molecule of mebendazole in the Yellow River carp could be CAT. The main target molecules of mebendazole to poison Yellow River carp may be CAT,and the activity of CAT can be used as indicator for the poisoning of the common carp.