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当前位置: 首页 > 文章 > 单次肌注亚硒酸钠硒在犊牛体内的药代动力学研究 黑龙江畜牧兽医 1995 (5) 12-15
Position: Home > Articles > A study of pharmaco kinetics on sodium selenite in calf by single muscleinjection Heilongjiang Animal Science and Veterinary Medicine 1995 (5) 12-15

单次肌注亚硒酸钠硒在犊牛体内的药代动力学研究

作  者：
王振隆;康世良;周建平;王伟;石发庆;王书林
单  位：
东北农业大学动物医学系
关键词：
硒;犊牛;药代动力学;亚硒酸钠;单次肌肉注射
摘  要：
实验研究了单次肌注(OAmg/kg)亚硒酸钠注射液后,不同时间采血,用荧光分光光度计测定血硒浓度。经微机处理获得出血硒浓度理论值及药动学参数。血硒浓度—时间曲线符合—室开放模型,最佳药时方程:Ci=0.8688×(e-0.0023t-e-15.8967t)。主要动力学参数:T_(1/2) Ka=0.05±0.01(hrε);T_(1/2) Kel=322.62±45.86(hrs);Tp=0.58±0.12(hrs);Cmax=0.8665±0.1031(μg/ml);AUC=387.26±45.51(mg/L·hrs)。按单剂量给药参数,用多剂量给药模型公式计算出多剂量给药参数。
译  名：
A study of pharmaco kinetics on sodium selenite in calf by single muscleinjection
作  者：
Wang Zhenlong, Kang Shiliang, Zhou Jianping, (Department of Veterinary Medicinc,Noltheast Agnultural University Harbin 150030)
关键词：
Words:Selenium,CaIf,pharmacokinetics.Sodium Selenite.SingleMusclc Injection.
摘  要：
In thes experiment,sodium selenite solution were used as singlemuscle injection(0.4mg/kg body weight) and the blood samples werecollected in different time. Selenium concentration in blood wereassayed by Fluori-spectrophotoncter. The true value of seleniumconcentration in biood were processed with MCPKP program,which isspccially designed for pharmacokinctics on microcomputer, and by whicbwe can obtain the theoretical value of selenium concentration in bloodand pharmaeokinetics parameters. The biood seienium coucentration-tinecurve accord with single compartment open model. The best drug-tinecpuation is Ci = 0.8688 × (c-0.0023t-e-15.89670 . The main kineticsparameteis are Tl/2Ka=0.05 ± 0.01 (hrs), Tl/2kel = 322.62±45.68(hrs),Tp = 0.58± 0.12(hrs),Cnax=0.8665± 0.1031(μg/ml),Auc-387.26± 45.51(mg/L.hrs). Based on single dosing parameters,the parameters for multipledosing were caculated by the formula of mutiple dowing models.

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