当前位置: 首页 > 文章 > 微小隐孢子虫感染对大鼠血清抗氧化功能的影响 中国农学通报 2006,22 (7) 32-34
Position: Home > Articles > Effect of Rats Infected with Cryptosporidium on Serum Antioxidant Activity Chinese Agricultural Science Bulletin 2006,22 (7) 32-34

微小隐孢子虫感染对大鼠血清抗氧化功能的影响

作  者:
刘德义;顾有方;唐景峰;陈会良
单  位:
安徽科技学院
关键词:
隐孢子虫;抗氧化;大鼠;血清
摘  要:
40只SD大鼠随机分为4组(n=10),即空白对照组、地塞米松及氢化可的松免疫抑制隐孢子虫感染组、非免疫抑制隐孢子虫感染组。免疫抑制感染组和非免疫抑制感染组大鼠一次口服接种1×103个/ml卵囊1ml,空白对照组口服1ml生理盐水。于感染前(0d)和感染后2、7、13、19d采集血样,检测大鼠血清丙二醛(MDA)的含量和超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)活性的变化。结果表明:大鼠接种隐孢子虫后,免疫抑制感染组大鼠CAT活性在感染后缓慢下降,但与空白对照组相比变化不明显;MDA含量高于空白对照组(P<0.05),SOD活性低于空白对照组(P<0.05);而GSH-Px活性先升高后降低。非免疫抑制感染组大鼠和空白对照组相比无显著差异。
译  名:
Effect of Rats Infected with Cryptosporidium on Serum Antioxidant Activity
作  者:
Liu Deyi, Gu Youfang, Tang Jingfeng, Chen Huiliang (Anhui Science and Technology University, Fengyang 233100)
关键词:
Cryptosporidium, Antioxidant, Rat, Serum
摘  要:
40 rats were randomly divided into control group, Hydrocortisone and Dexamethasone immune-inhibition infection groups, no immune-inhibition infection group. The two latter groups' rats were dosed orally 1×103 Cryptosporidiums, control group rats were not dosed. Pre-infection 0 day and post-infection 2,7,13 and 19days, the blood samples were collected to determine MDA, SOD, GSH-Px and CAT. Results showed that Immune-inhibition infection group rats post-infection Cryptosporidium, the serum CAT activity dropped. But control group rats were no obvious change .The content of MDA was higher control group (p<0.05), but SOD activity was lower (p<0.05).GSH-Px activity was increased then decreased .No immune-inhibition infection and control groups rats weren't significant.

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