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Position: Home > Articles > Synthesis of Dicyclanil, an Insect Growth Regulator Modern Agrochemicals 2015,14 (3) 32-33+39

昆虫生长调节剂环虫腈的合成研究

作  者:
王学成;苏文杰;朱建民
单  位:
江苏省兽用抗寄生虫药物工程技术研究中心
关键词:
昆虫生长调节剂;环虫腈;合成;双氰胺钠
摘  要:
报道了环虫腈合成新工艺。以双氰胺钠和丙二腈为起始原料,经缩合和环合反应制备2-氯-4,6-二氨基嘧啶-5-腈,再与环丙胺进行取代反应得到目标产物环虫腈,3步反应总收率大于64%,产品质量分数99%以上。环虫腈及其中间体的化学结构经核磁共振氢谱、核磁共振碳谱、质谱和红外光谱确认。
译  名:
Synthesis of Dicyclanil, an Insect Growth Regulator
作  者:
WANG Xue-cheng;SU Wen-jie;ZHU Jian-min;Jiangsu Veterinary Antiparastics Engineering Research Center;
关键词:
IGR;;dicyclanil;;synthesis;;sodium dicyanamide
摘  要:
An improved synthetic process of dicyclanil was reported in this paper. The target product was prepared by reaction of cyclopropylamine and 2-chloro-4,6-diamino-5-pyrimidinecarbonitrile which was obtained via condensation and cyclization reactions by using dicyanamide and malonitrile as starting materials. The total yield for three steps of the process was more than 64%, the purity of dicyclanil over 99%. The chemical structures of dicyclanil and its intermediates were confirmed by1 H NMR,13 C NMR, MS and IR.

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