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Position: Home > Articles > Synthesis Methods of the Third Generation Nicotinic Insecticide——Dinotefuran Modern Agrochemicals 2008,7 (6) 17-19

第三代烟碱类杀虫剂呋虫胺的合成

作  者:
戴炜锷;蒋富国;程志明
单  位:
浙江海正化工股份有限公司;上海生农生化制品有限公司
关键词:
烟碱;杀虫剂;呋虫胺;合成方法
摘  要:
叙述了第三代烟碱类杀虫剂呋虫胺的5种合成方法。采用"(四氢-3-呋喃)-甲基对甲苯磺酸酯"的合成方法进行了试验。(四氢-3-呋喃)甲醇用对甲苯磺酰氯酯化,甲基硝基胍用甲醛、甲胺环化,1,5-二甲基-2-硝基亚胺六氢-1,3,5-三嗪和3-四氢呋喃甲基对甲苯磺酸酯缩合,分解制得呋虫胺。总收率60.5%(以甲基硝基胍计),含量98%。该法最易工业化。
译  名:
Synthesis Methods of the Third Generation Nicotinic Insecticide——Dinotefuran
作  者:
DAI Wei-e1,JIANG Fu-guo1,CHENG Zhi-ming2(1.Zhejiang Hisun Chemical Co.,Ltd.,Zhejiang Taizhou 318000,China;2.Shanghai Shengnong Pesticide Co.,Ltd.,Shanghai 200122,China)
关键词:
nicotine;insecticide;dinotefuran;synthesis methods
摘  要:
Five synthesis methods of the third generation nicotinic insecticide——dinotefuran are discussed.The excellent industrial synthesis is the method of "(tetrahydro-3-furanyl)-methyltosylate".The(tetrahydro-3-furanyl) methanol is esterified with the p-toluenesulfonyl chloride.The N-methyl-N'-nitroguanidine is cyclized with the methylamine and formaldehyde.The(tetrahydro-3-furanyl)-methyltosylate and 1,5-dimethyl-2-nitroiminohexahydro-1,3,5-triazine is condensed and decomposited to obtain dinotefuran.Total yield is 60.5%(calculate by N-methyl-N'-nitroguanidine).The content is 98%.

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