Position: Home > Articles > ULTRASTRUCTURAL STUDIES ON EFFECT OF He-Ne LASER PLUS HpD ON S180 FIBROSARCOMA
Chinese Journal of Animal and Veterinary Sciences
1990,21
(3)
263-267
低功率氦氖激光加血卟啉衍生物杀伤肿瘤细胞的超微结构研究
作 者：
谢慧胜;于船
单 位：
北京农业大学兽医学院
关键词：
透视电镜;低功率氦氖激光;小鼠S180纤维肉瘤;血卟啉衍生物
摘 要：
用低功率氦氖激光-血卟啉衍生物(HpD)所产生的光动力学(PDT)效应治疗小鼠S180纤维肉瘤已获得了一定的实验性疗效,在此基础上进行了PDT杀伤肿瘤细胞的超微结构研究。电镜观察结果发现:PDT疗法治疗后第1天,肿瘤细胞线粒体肿胀,有的线粒体的嵴断裂;第3天,线粒体基质聚集而出现空化灶,嵴消失,内质网扩张,微绒毛减少;治疗后第7天,线粒体基质溶解呈空泡化,细胞膜破坏,胞浆内有空泡,可见胞浆内容物溢出胞外,核糖体减少,核膜部分破坏,染色质聚集成团,核膜破坏消失;13天,细胞核溶解,核内容物溢出胞外。
译 名：
ULTRASTRUCTURAL STUDIES ON EFFECT OF He-Ne LASER PLUS HpD ON S180 FIBROSARCOMA
作 者：
Xie Huisheng, Yu Chuan ( Department of Veterinary Medicine, Beijing Agricultural University )
关键词：
TEM, He-Ne laser, S180 fibrosarcoma, HpD
摘 要：
The matrices of some mitochondria were observed to gather or assemble and degenerate at first with the TEM,and then the membrane of the cells, nucleis, endoplasmic reticula ( ER), microvilli and ribosomes were observed to be destroyed to some extent. The gap of the cell membrane and nucleis were enlarged, and vacuoles in the cytoplasm increased. The contents of the cytoplasm and nucleis were solved and destroyed and at last escaped from the tumour cells. The changes of the ultrastructure described above may be the principle of the killing effect on the tumour cells with PDT.
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