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当前位置: 首页 > 文章 > 武定鸡和科宝肉鸡成骨细胞矿化及TNF-α基因表达差异研究 中国家禽 2019 (6) 7-10
Position: Home > Articles > Study on Mineralization and TNF-α Gene Expression of Osteoblasts in Wuding Chicken and Cobb Broiler China Poultry 2019 (6) 7-10

武定鸡和科宝肉鸡成骨细胞矿化及TNF-α基因表达差异研究

作  者：
豆腾飞;赵净颖;王秋婷;段小花;李涛;徐志强;谷大海;葛长荣;贾俊静
单  位：
云南农业大学食品科学技术学院;云南中医学院;云南农业大学动物科学技术学院云南省动物营养与饲料重点实验室
关键词：
武定鸡;科宝肉鸡;间充质干细胞;成骨细胞;TNF-α基因
摘  要：
为研究武定鸡和科宝肉鸡成骨细胞分化、矿化及肿瘤坏死因子α(TNF-α)基因表达差异,试验通过提取武定鸡和科宝肉鸡骨间充质干细胞,并诱导分化为成骨细胞,检测成骨细胞分化、矿化差异及TNF-α基因表达差异。结果显示:与科宝肉鸡相比,在骨间充质干细胞诱导为成骨细胞过程中,武定鸡成骨细胞矿化能力较强,且TNF-α基因表达量显著低于科宝肉鸡。研究表明:TNF-α可通过调控成骨细胞分化来影响矿化过程,进而影响骨骼强度。可见,TNF-α基因对家鸡成骨细胞矿化起着重要的作用。
译  名：
Study on Mineralization and TNF-α Gene Expression of Osteoblasts in Wuding Chicken and Cobb Broiler
作  者：
DOU Tengfei;ZHAO Jingying;WANG Qiuting;DUAN Xiaohua;LI Tao;XU Zhiqiang;GU Dahai;GE Changrong;JIA Junjing;Faculty of Animal Science and Technology, Yunnan Provincial Key Laboratory of Animal Nutrition and Feed, Yunnan Agricultural University;Yunnan University of TCM;College of Food Science and Technology,Yunnan Agricultural University;
单  位：
DOU Tengfei%ZHAO Jingying%WANG Qiuting%DUAN Xiaohua%LI Tao%XU Zhiqiang%GU Dahai%GE Changrong%JIA Junjing%Faculty of Animal Science and Technology, Yunnan Provincial Key Laboratory of Animal Nutrition and Feed, Yunnan Agricultural University%Yunnan University of TCM%College of Food Science and Technology,Yunnan Agricultural University
关键词：
Wuding chickens;;Cobb broilers;;bone mesenchymal stem cells;;osteoblasts;;TNF-α gene
摘  要：
In order to study differences on differentiation, mineralization and TNF-α gene expression of osteoblast in Wuding chicken and Cobb broiler, bone mesenchymal stem cells from Wuding chicken and Cobb broiler were obtained to induce into osteoblasts. Differentiation and mineralization of osteoblast and expression of TNF-α in osteoblasts were detected. The results showed that compared with the Cobb broiler, in the process of induced into osteoblasts, the mineralization ability of Wuding chicken was stronger than that in Cobb broiler. And the expression of TNF-α gene in osteoblasts from Wuding chicken was significantly lower than that in Cobb broiler. It indicated that TNF-α gene could affect bone strength by regulating osteoblast differentiation to influence mineralization process. So, it can be seen that TNF-α gene plays an important role in the mineralization of chicken osteoblasts.

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