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Position: Home > Articles > THE ULTRASTRUCTURAL CHANGES IN EIMERIA TENELLA NFECTING CHICKENS AFTER EXPOSURE TO THE ANTICOCCIDIAL DRUG 80334 (ANTHRACYCLINE) Scientia Agricultura Sinica 1986,19 (5) 77-80+96-97

蒽环类抗生素80334对柔嫩艾美尔球虫作用后裂殖体阶段超微结构的观察

作  者:
李渌;史天卫;张惠英;韩志华;黄兵;吴薛忠
单  位:
中国农业科学院上海家畜血吸虫病研究所
摘  要:
蒽环类(Anthcacycline)抗生素80334是一个新的抗球虫药物,它对革兰氏阳性菌,Hele肿瘤细胞株、L-1210白血球细胞株等有强抑制作用。1981年日本味之素公司首次报道了蒽环类抗生素具有防治鸡球虫病的作用。童村、史天卫等1983年在我国首次报告亦证明该抗生素对球虫病的效果。 为了探讨蒽环类抗生素80334抗柔嫩艾美尔球虫(Eimeria tenella)的作用机制,我们通过用药与不用药进行对照,观察了球虫裂殖体阶段超微结构的变化,供深入研究药物作用机制及原虫生理生化时参考。
译  名:
THE ULTRASTRUCTURAL CHANGES IN EIMERIA TENELLA NFECTING CHICKENS AFTER EXPOSURE TO THE ANTICOCCIDIAL DRUG 80334 (ANTHRACYCLINE)
作  者:
Li Lu Shi Tianwei Zhang Huiying Han Zhihua Huang Bin Wu Xuezhong (Shanghai Institute of Schistosomiasis of Domestic Animals, Chinese Academy of Agricultural Sciences, Shanghai)
摘  要:
The ultrasturcture of the schizonts of E. tenella has been studied by means of electron microscopy. When the schizonts ot E. tenella were treated by the antibiotic 80334, gradual changes of the ultrastructure of the second generation of schizonts were observed.A group of chicken, each inoculated Orally with sporulated oocysts, is compared with another group of chicken which was each inoculated orally with sporulated oocysts but treated with the drug. The 80334 interfered with the development of the membranes of the second schizonts, and in the meantime, a lot of leucocytes occurred in the inherent membranes. The mechanism of the function of 80334 and the immune reaction in the host were discussed.

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