Position: Home > Articles > Distribution of HOMA-IR Index and Its Relationship with Body Composition in Overweight/Obesity Children Aged 8 to 10 Years
Food and Nutrition in China
2019
(11)
70-73
8～10岁超重肥胖儿童HOMA-IR指数分布及与人体成分的相关性研究
作 者：
杨文利;闫洁;赵文利;杨秀花;潘长鹭;栗达;夏露露;杨炯贤;桑艳梅;魏云芳;王银会;许嘉;巴蕾
单 位：
北京市朝阳区疾病预防控制中心;国家儿童医学中心/首都医科大学附属北京儿童医院临床营养科;国家儿童医学中心/首都医科大学附属北京儿童医院内分泌及遗传代谢中心
关键词：
HOMA-IR指数;人体成分;超重;肥胖;儿童
摘 要：
目的:探讨8～10岁超重肥胖儿童稳态胰岛素评估模型胰岛素抵抗(HOMA-IR)指数的分布及与人体成分等测量指标的关系。方法:以2018年北京市某小学8～10岁超重肥胖儿童为研究对象,采集人体测量指标(体质量、身高、体质量指数、腰臀比)、人体成分指标(肌肉量、去脂体重量、体脂肪、体脂百分比、内脏脂肪面积、基础代谢率),检测血液空腹血糖、胰岛素水平,采用HOMA-IR指数评估胰岛素抵抗。结果:共收集149名儿童,其中超重57名、肥胖92名;肥胖者体质量指数、腰臀比、体脂肪、体脂百分比、空腹胰岛素、内脏脂肪面积、HOMA-IR指数均显著高于超重者,两者空腹血糖比较无显著差异(P=0. 108)。男生(109例)在肌肉量、去脂体重、基础代谢率方面大于女生(40例)(P <0. 05)。48例(32. 2%)儿童存在胰岛素抵抗状态(IR> 4),且各检测指标均显著升高(P<0. 001)。体质量指数、腰臀比、体脂肪、体脂百分比、内脏脂肪面积均与HOMA-IR指数呈显著正相关(P <0. 001),其中腰臀比相关性最大(r=0. 472)。结论:超重肥胖儿童HOMA-IR指数普遍偏高。HOMA-IR指数大于4时,体重、BMI、体脂肪、体脂百分比、内脏脂肪面积等显著增加。人体成分分析可用于超重肥胖儿童体格评估。
译 名：
Distribution of HOMA-IR Index and Its Relationship with Body Composition in Overweight/Obesity Children Aged 8 to 10 Years
作 者：
YANG Wen-li;YAN Jie;ZHAO Wen-li;YANG Xiu-hua;PAN Chang-lu;LI Da;XIA Lu-lu;YANG Jiong-xian;SANG Yan-mei;WEI Yun-fang;WANG Yin-hui;XU Jia;BA Lei;National Center for Children's Health/Department of Clinical Nutrition,Beijing Children's Hospital,Capital Medical University;National Center for Children's Health/Department of Endocrinology,Genetics and Metabolic Disorders,Beijing Children's Hospital,Capital Medical University;Chaoyang District Center for Disease Control and Prevention;
关键词：
HOMA-IR index;;body composition;;overweight;;obesity;;children
摘 要：
Objective To investigate the distribution of homeostasis model assessment-insulin resistance(HOMA-IR) index and its relationship with body composition in overweight/obesity children aged 8 to 10 years. Method We selected overweight/obesity children aged 8 to 10 years in one primary school of Beijing city,including anthropometric parameters(height,body weight,body mass index,waist-hip ratio),body composition parameters(soft lean mass,fat free mass,body fat mass,percent body fat,visceral fat area,basal metabolic rate),fasting blood glucose,fasting insulin and insulin resistance was evaluated by HOMA-IR index. Result Totally 149 children(n =109 for boys and n = 40 for girls) were collected. The body mass index,waist-hip ratio,body fat mass,percent body fat,visceral fat area,fasting insulin and HOMA-IR index of obesity group(n = 92) were significant higher than overweight group(n = 57),but there was no difference in fasting blood-glucose. Except soft lean mass,fat free mass and basal metabolic rate,the other parameters were no significant difference between boys and girls. 48 cases(32. 2%) were insulin resistance state(IR > 4). When HOMA-IR index surpassed 4,all parameters were significantly increased(P < 0. 001). Body mass index,waist-hip ratio,body fat mass,percent body fat,visceral fat area were positively related to HOMA-IR index(P < 0. 001),especially waist-hip ratio. Conclusion The HOMA-IR index in overweight/obesity children were increased. When HOMA-IR index surpassed 4,all parameters were significantly increased. The measurement of body composition plays an important role in overweight/obesity children.
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