Position: Home > Articles > STUDY ON PREPARATION AND APPLICATION OF SODIUM ALGINATE HYDROGEL MODIFIED BY ORGANIC AMINE
Transactions of Oceanology and Limnology
2013
(4)
130-134
有机胺改性海藻酸钠凝胶微球的制备及对药物的缓释作用
作 者：
许同桃;高健;杨姗姗
单 位：
江苏省海洋资源开发研究院;连云港职业技术学院医药与化学工程学院
关键词：
正己胺;正庚胺;海藻酸钠;凝胶;阿德福韦;β-榄香烯
摘 要：
通过正己胺、正庚胺对海藻酸钠进行疏水改性,采用乳化-内部凝胶化技术分别制得负载小分子抗肿瘤药物β-榄香烯和小分子抗病毒药物阿德福韦的改性海藻酸钠凝胶微球,通过色谱法考察体外释放性能。正己胺、正庚胺改性海藻酸钠凝胶微球对药物β-榄香烯和阿德福韦的负载能力提高,且具有优良的缓释性能。改性凝胶微球对两种药物的包埋率都超过85%,48h体外累释放率超过55%。
译 名：
STUDY ON PREPARATION AND APPLICATION OF SODIUM ALGINATE HYDROGEL MODIFIED BY ORGANIC AMINE
作 者：
XU Tongtao;GAO Jian;YANG Shanshan;College of Pharmaceutical and Chemical Engineering,Lianyungang Technical College;Jiangsu Province Marine Resources Development Research Institute;
关键词：
hexyl amine;;heptyl amine;;sodium alginate;;hydrogel;;adefovir;;β-Elemene
摘 要：
Sodium alginate was hydrophobically modified through hexyl amine and heptyl amine.Load of small molecular anticancer drugsβ-Elemene and antiviral drugs adefovir modified alginate gel microspheres were prepared by emulsification-internal gelatification technology,and In vitro drug release property was examined using gas chromatography.The modified alginate hydrogel has higher capacity and better sustained release toβ-Elemene and adefovir than unmodified alginate hydrogel,respectively.
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