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Animal Husbandry & Veterinary Medicine
2019
(1)
10-16
美洲水貂TYR基因编码蛋白结构及功能的生物信息学分析
作 者：
王亚琪;胡露露;王瑞宁;刘铮铸;巩元芳;李祥龙;彭永东
单 位：
河北科技师范学院动物科技学院
关键词：
酪氨酸酶相关蛋白;美洲水貂;毛色;蛋白质结构;生物信息学
摘 要：
为进一步探明美洲水貂酪氨酸酶(TYR)基因的结构和功能信息,对美洲水貂TYR基因编码蛋白进行生物信息学分析,同时构建TYR基因的系统发育树。结果表明:美洲水貂TYR基因共编码531个氨基酸,其编码产物为不稳定的亲水蛋白;二级结构主要以α-螺旋和无规卷曲为主,含有1个酪氨酸酶超家族结构域,存在信号肽、跨膜结构域和二硫键;该蛋白主要在内质网中发挥细胞被膜、运输和结合的作用,同时还通过信号转导在细胞内发挥其生物学作用;系统进化情况和动物分类学基本一致,美洲水貂TYR基因与雪貂、家犬的亲缘关系最近。美洲水貂TYR基因编码蛋白在生物进化中具有较强保守性,该基因结构和功能的分析为水貂TYR基因遗传特性的进一步研究奠定了基础。
译 名：
Bioinformatic analysis of the structure and function of TYR-gene-encoding protein in American mink
作 者：
WANG Yaqi;HU Lulu;WANG Ruining;LIU Zhengzhu;GONG Yuanfang;LI Xianglong;PENG Yongdong;College of Animal Science and Technology,Hebei Normal University of Science and Technology;
单 位：
WANG Yaqi%HU Lulu%WANG Ruining%LIU Zhengzhu%GONG Yuanfang%LI Xianglong%PENG Yongdong%College of Animal Science and Technology,Hebei Normal University of Science and Technology
关键词：
TYRP1;;American mink;;coat color;;protein structure;;bioinformatics
摘 要：
In order to further understand the structural and functional information of the TYR gene of American mink,the TYR-gene-encoding protein of the animal was analyzed by bioinformatic methods,and the phylogenetic tree of the TYR gene was constructed. The results showed that the TYR gene of American mink encoded 531 amino acids,and its encoding product was unstable hydrophilicity protein. Its secondary structure was mainly composed of alpha helix and random coil,containing one tyrosinase superfamily domain,some signal peptides,transmembrane domains,and disulfide bonds. The protein mainly played a role of cell envelope,transport and binding in the endoplasmic reticulum,and also exerted its biological effect in the cell through signal transduction. The phylogenetic situation was basically consistent with that of animal taxonomy. The TYR gene of American mink was closely related to domestic cats and domestic dogs. The protein encoded by the TYR gene was highly conservative in biological evolution. The analysis of the structure and function of this gene here laid the foundation for further study of the genetic characteristics of the TYR gene of mink.
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