当前位置: 首页 > 文章 > 百合多糖对Ⅰ型糖尿病大鼠的降血糖作用 食品科学 2014,35 (1) 209-213
Position: Home > Articles > Hypoglycemic Effect of Lily Polysaccharides in Type Ⅰ Diabetic Rats FOOD SCIENCE 2014,35 (1) 209-213

百合多糖对Ⅰ型糖尿病大鼠的降血糖作用

作  者:
肖遐;吴雄;何纯莲
单  位:
湖南师范大学医学院
关键词:
百合多糖;I型糖尿病;胰岛素;超氧化物歧化酶
摘  要:
目的:探讨百合多糖对I型糖尿病大鼠的降血糖作用。方法:从新鲜百合中提取出百合多糖,采用离子交换层析和凝胶层析纯化得到3种多糖;优选碱洗百合多糖、以链脲佐菌素诱导建立I型糖尿病大鼠模型,通过百合多糖治疗,比较治疗前后大鼠体质量及空腹血糖的变化、测定治疗后胰岛素水平以及己糖激酶、琥珀酸脱氢酶、总超氧化物歧化酶的活性和丙二醛的含量,研究百合多糖对I型糖尿病大鼠的降血糖作用。结果:百合多糖可减缓糖尿病大鼠体质量的负增长;降低空腹血糖(P<0.01)和丙二醛含量(P<0.05);升高胰岛素、己糖激酶、琥珀酸脱氢酶和总超氧化物歧化酶活性(P<0.01)。结论:百合多糖一方面通过提高糖代谢酶的活性,促进葡萄糖的摄取和利用;另一方面通过提高机体抗氧化功能,抑制氧自由基对胰岛β细胞的损伤,增加胰岛素分泌,调节I型糖尿病大鼠的血糖。
译  名:
Hypoglycemic Effect of Lily Polysaccharides in Type Ⅰ Diabetic Rats
作  者:
XIAO Xia;WU Xiong;HE Chun-lian;Medical College,Hunan Normal University;
关键词:
lily polysaccharide;;type I diabetic rats;;insulin(INS);;superoxide dismutase(SOD)
摘  要:
Objective: To explore the hypoglycemic effect of lily polysaccharides in type Ⅰ diabetic rats. Methods: Lily polysaccharide was extracted from fresh lily bulbs and purified through ion-exchange chromatography on a DEAE52 cellulose column. An alkaline-soluble fraction was obtained from the eluates from the DEAE52 cellulose column and proved to be a single component by gel filtration chromatography. The purified polysaccharide was used to treat rat models of t ype Ⅰ diabetes induced b y streptozotocin. The changes in body weight, fasting blood gluco se(FBG), insulin(INS), hexokinase(HK), succinic dehydrogenase(SDH), total superoxide dismutase(T-SOD) and malondialdehyde(MDA) were determined in diabetic rats before and after the treatment. Results: The lily polysaccharide could significantly slow down the negative growth of body weights in diabetic rats, reduce the contents of FBG(P < 0.01) and MDA(P < 0.05), and significantly increase INS, HK, SDH and T-SOD(P < 0.01). Conclusion: Lily polysaccharide exerts hypoglycemic effect in type Ⅰ diabetic rats through enhancing the activities of antioxidant enzymes, improving antioxidant function, inhibiting oxygen free radical damage to pan creatic β cells and increasing insulin secretion.

相似文章

计量
文章访问数: 14
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊