Position: Home > Articles > Safety evaluation of compound Amoxicillin and Levofloxacin hydrochloride nanoemulsion
Journal of Henan Agricultural University
2011,45
(5)
68-73
复方阿莫西林纳米乳制剂的安全性评价
作 者：
杨雪峰;姜金庆;孙红武;欧阳五庆
单 位：
河南科技学院动物科学学院;西北农林科技大学动物医学院
关键词：
复方阿莫西林纳米乳;急性毒性;皮肤刺激性;细胞毒性;安全性评价
摘 要：
通过急性毒性试验、皮肤刺激性试验和细胞毒性试验,对复方阿莫西林纳米乳(AMX-LH-NE)进行体内外安全性评价.结果表明,AMX-LH-NE毒性低,无法测出其半数致死量,小鼠的最大耐受量倍数为426倍;无论是单次给药,还是多次给药,AMX-LH-NE对完整皮肤和破损皮肤均无明显刺激性;AMX-LH-NE为10～150 mg.L-1时,对乳腺上皮细胞的生长和形态无明显影响,其毒性分级属于0或1级,即对乳腺上皮细胞无毒性作用.
译 名：
Safety evaluation of compound Amoxicillin and Levofloxacin hydrochloride nanoemulsion
作 者：
YANG Xue-feng1,2,JIANG Jin-qing1,SUN Hong-wu2,3,OUYANG Wu-qing2(1.College of Animal Science,Henan Institute of Science and Technology,Xinxiang,453003,China; 2.College of Veterinary Medicine,Northwest A&F University,Yangling,712100,China; 3.College of Pharmacy,Third Military Medical University,Chongqing 400038,China)
关键词：
compound Amoxicillin and Levofloxacin hydrochloride nanoemulsion;acute toxicity;skin irritation;cytotoxicity;safety evaluation
摘 要：
The safety of compound Amoxicillin and Levofloxacin hydrochloride nanoemulsion(AMX-LH-NE) was evaluated in vivo and in vitro by acute toxicity test,skin irritation test and cytotoxic test.The results showed that the toxicity of AMX-LH-NE was low and its half lethal dose was impossibly measured.The maximum tolerable dose to mice was 426 times.Obvious irritation didn't appear regardless of single or multiple dosing when AMX-LH-NE was used on complete and damaged skin of rabbits respectively.There was no obvious influence of AMX-LH-NE on growth and appearance of mammary epithelial cells at the concentration of 10 to 150 mg·L-1,and its toxicity grade was 0 or 1.In other words,AMX-LH-NE had no cytotoxicity against mammary epithelial cells.
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