Position: Home > Articles > In vitro Antioxidant Activity and in vivo Anti-Aging Effect of Tilapia Skin Gelatin Hydrolysates
FOOD SCIENCE
2016,37
(15)
221-226
罗非鱼皮胶原蛋白水解产物的体外抗氧化活性和体内抗衰老作用
作 者：
周先艳;樊建;唐远龙;庄永亮;孙丽平
单 位：
昆明理工大学云南省食品安全研究院
关键词：
罗非鱼皮胶原蛋白水解产物;氨基酸组成;抗氧化活性;抗衰老
摘 要：
对罗非鱼皮胶原蛋白水解制备水解产物(tilapia skin gelatin hydrolysate,TSGH),分离得到3个肽组分(TSGH-1、TSGH-2和TSGH-3),分析肽组分氨基酸组成,并对TSGH-3的体外抗氧化活性和体内抗衰老能力进行评价。结果表明:TSGH-3的分子质量低,疏水性氨基酸含量高,从自由基清除和金属螯合两个方面证实了TSGH-3具有很好的体外抗氧化活性。TSGH-3能显著增加由D-半乳糖诱导衰老大鼠的血清、肝脏和肾脏组织的总抗氧化能力、超氧化物歧化酶和谷胱甘肽过氧化物酶活性,并且能显著降低丙二醛的含量。此外,TSGH-3的摄入可以保护大鼠的肝脏和肾脏指数。因此,TSGH-3在抗氧化、抗衰老方面具有较好的应用潜力。
译 名：
In vitro Antioxidant Activity and in vivo Anti-Aging Effect of Tilapia Skin Gelatin Hydrolysates
作 者：
ZHOU Xianyan;FAN Jian;TANG Yuanlong;ZHUANG Yongliang;SUN Liping;Yunnan Institute of Food Safety, Kunming University of Science and Technology;
关键词：
tilapia skin gelatin hydrolysates;;amino acid composition;;antioxidant activity;;anti-aging
摘 要：
The amino acid composition of three peptides fractions(TSGH-1, TSGH-2 and TSGH-3) separated from tilapia skin gelatin hydrolysate(TSGH) was measured. Additionally, the antioxidant activity in vitro and anti-aging capacity in vivo of TSGH-3 were evaluated. The results showed TSGH-3 had low molecular weight and high hydrophobic amino acid contents. TSGH-3 had high antioxidant activity in vitro in terms of free radical scavenging and metal chelating activity. Furthermore, the in vivo anti-aging activity in a D-galactose-induced aging mouse model indicated that TSGH-3 could significantly increase T-AOC, SOD and GSH-Px activities in serum, liver and kidney tissues of rats(P < 0.05), and significantly decreased MDA contents(P < 0.05). Besides, liver and kidney indices of rats could be also protected after the intake of TSGH-3. Therefore, TSGH-3 possesses high antioxidant activity and can be used as a natural anti-aging agent in the medicinal and food industries.
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